Oral disintegrating patient-tailored tablets of warfarin sodium produced by 3D printing

Drug Development and Industrial Pharmacy
Pan TianYan-Zhong Chen

Abstract

Individualized medicine is a new direction in the field of modern pharmacy. In this study, we assessed the feasibility and accuracy of 3D printing techniques for the preparation of individualized doses of mouth-disintegrating tablets of warfarin. Warfarin sodium, D-sucrose, pregelatinized starch, povidone K30, microcrystalline cellulose, and silicon dioxide (at a ratio of 1:42.45:46.15:5.1:4.9:0.4) were mixed and used as the printing powder in the 3D printer; preset parameters were used. The dosage of the tablet was controlled by the number of printing layers. The content, dose uniformity, dose accuracy, hardness, friability, disintegration time, dissolution, and the microstructural and overall appearance were determined to evaluate the printed tablets. For the doses of 3, 2, and 1 mg that were produced in the experiment, the disintegration times were 50.0 ± 5.2, 35.7 ± 4.3, and 11.0 ± 2.2 s, respectively, and the relative errors of the dose were -2.33, -1.50, and 0%, respectively. The other indicators were consistent with the preparation requirements of pharmaceutical tablets. It is possible to prepare tablets with excellent properties and controlled drug doses by using 3D printing techniques. This technology will be an import...Continue Reading

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Citations

Feb 13, 2019·Drug Development and Industrial Pharmacy·Pan TianYan-Zhong Chen
Feb 23, 2020·Drug Development and Industrial Pharmacy·Xiaoting WangFan Yang
Jul 28, 2020·Drug Development and Industrial Pharmacy·Melissa WallisAli Nokhodchi
Sep 4, 2019·Expert Opinion on Drug Delivery·Sarah J TrenfieldAbdul W Basit
Sep 7, 2020·International Journal of Pharmaceutics·R Durga Prasad Reddy, Varun Sharma
Oct 9, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiaoyan XuAbdul W Basit
Aug 28, 2021·Advanced Drug Delivery Reviews·Koyel SenBodhisattwa Chaudhuri
Sep 4, 2021·Advanced Drug Delivery Reviews·Atheer AwadAbdul W Basit
Oct 7, 2021·Drug Delivery and Translational Research·Rabinarayan Parhi, Goutam Kumar Jena

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