Oral disodium cromoglycate treatment of atopic dermatitis

Allergy
R Lindskov, L Knudsen

Abstract

Fourteen adults and 10 children with active atopic dermatitis entered this double blind cross-over study of oral disodium cromoglycate (DSCG) (adults 200 mg qid, children 100 mg qid) compared with placebo. Oral DSCG and placebo were given for 6 weeks in random order. According to the investigators' assessments of eczema, significant differences between active and placebo were found after 6 weeks' treatment, DSCG being favoured (P less than 0.05). No differences were detected in the investigators' assessment of lichenization and overall disease. No significant differences between the two treatments were demonstrated in the patients' assessments. Results from food allergic patients were similar to those from non-food allergic patients. Two patients reported possible side effects of arthralgia and urticaria respectively. There were no treatment effects on serum IgE values or any other laboratory data.

References

May 20, 1978·Lancet·G A VazJ W Gerrard
Mar 1, 1977·Clinical Allergy·A DannaeusS G Johansson
Jul 1, 1972·The Journal of Pharmacy and Pharmacology·S R WalkerJ W Paterson
Mar 1, 1980·Allergy·J ThormannH Zachariae
Jun 1, 1982·The British Journal of Dermatology·D J AthertonJ Elvidge

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Citations

Mar 1, 1985·The British Journal of Dermatology·M AriyanayagamJ M Harris
Apr 1, 1987·International Journal of Dermatology·H L Roth

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Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.