Oral dolasetron mesylate for prevention of postoperative nausea and vomiting: a multicenter, double-blind, placebo-controlled study. The Oral Dolasetron PONV Prevention Study Group

Journal of Clinical Anesthesia
P DiemunschR A Brown

Abstract

To examine the safety and effectiveness of a range of single oral doses of dolasetron mesylate for the prevention of postoperative nausea and vomiting. Randomized, double-blind, placebo-controlled trial. 32 hospitals. 789 female ASA physical status I, II, and III patients, ages 18 to 60 years, weighing between 45 and 100 kg, scheduled for major gynecologic surgery (including abdominal hysterectomy, gynecologic laparotomy, or vaginal hysterectomy) with general anesthesia. 25, 50, 100, or 200 mg oral doses of dolasetron mesylate or placebo were administered 1 to 2 hours before induction of anesthesia. Efficacy was assessed for 24 hours postrecovery by measuring complete response (no emetic episodes, no rescue medication), total response (complete response with no nausea), time to first emetic episode or rescue, and patient visual analog scale evaluations of nausea severity and satisfaction with antiemetic therapy. Complete response rates for the 50, 100, and 200 mg dose groups were statistically greater than placebo (p < or = 0.018). Likewise, total response rates were statistically greater in the 50, 100, and 200 mg dose groups than in the placebo group (p = 0.012). Percentage of patients with no nausea and patient satisfaction ...Continue Reading

References

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Citations

Oct 1, 1973·British Journal of Urology·A J Linhares Furtado
Sep 18, 2004·Journal of Clinical Anesthesia·Kari T Korttila, Jeremy D Jokinen
Aug 19, 2003·The Annals of Pharmacotherapy·Rudolph M Navari, Jim M Koeller
Jun 19, 2003·Anesthesiology Clinics of North America·David Cameron, Tong Joo Gan
Oct 6, 2006·Current Opinion in Anaesthesiology·Mehernoor F Watcha
Oct 23, 2002·Paediatric Drugs·Pasquale De Negri, Giorgio Ivani
Jul 18, 2017·The Cochrane Database of Systematic Reviews·John Carlisle, Carl A Stevenson
Oct 4, 2006·Current Opinion in Anaesthesiology·J ScholzP H Tonner
Oct 20, 2020·The Cochrane Database of Systematic Reviews·Stephanie WeibelPeter Kranke
Jan 27, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Naoko NiimiKatherine Zaleski
Feb 24, 2001·Gastroenterology·E M QuigleyH P Parkman

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