Oral doxycycline with topical tacrolimus for treatment of stasis dermatitis due to chronic venous insufficiency: A pilot study.

Indian Journal of Pharmacology
Niteeka MarooSuparna Chatterjee

Abstract

Chronic venous insufficiency (CVI) in lower limbs manifest as stasis dermatitis. The anti-collagenase, anti-inflammatory and immunomodulatory effects of doxycycline and the T-cell inhibitory effects of tacrolimus could theoretically modify the disease pathophysiology. This study was undertaken to evaluate the efficacy and safety of four weeks combination therapy of oral doxycycline 100 mg with topical tacrolimus 0.1% for stasis dermatitis associated with CVI. A single-arm, interventional pilot study was conducted on subjects with CVI of C4 to C6 category (CEAP classification: clinical, etiology, anatomical, pathophysiology). Treatment duration was four weeks with fortnightly follow-ups. Primary efficacy was assessed as changes from baseline of pigmentation, erythema, edema, itching and hair loss of the affected area evaluated on Likert scale scores. Secondary efficacy parameters were percentage improvement of the dermatitis area and changes in ulcer dimensions (maximum length and breadth), if present. Safety evaluation included all treatment emergent clinical signs and symptoms reported by the patients and/or observed by the physician. Out of 19 recruited subjects, 15 completed the study for analysis. Significant (P<0.01) impro...Continue Reading

References

May 30, 1998·Rheumatology International·D NordströmY T Konttinen
Mar 10, 2001·Journal of Dermatological Science·Y HerouyJ Norgauer
Dec 30, 2004·VASA. Zeitschrift für Gefässkrankheiten·J DissemondM Goos
Nov 23, 2005·Archives of Dermatology·Jamie MackelfreshJack L Arbiser
Jun 3, 2009·Current Vascular Pharmacology·Chung S LimAlun H Davies
Dec 4, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M Perrin, A A Ramelet

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