Oral drug delivery research in Europe

Journal of Controlled Release : Official Journal of the Controlled Release Society
Randall J Mrsny

Abstract

The oral delivery of drugs is considered by decision-makers in the pharmaceutical industry to be the most appealing route of administration. This belief has led to the identification of many very successful drugs, but also to the downfall of some promising therapeutics that failed to meet criteria required for sufficient oral bioavailability. Efforts to correct these deficiencies have led to a plethora of creative strategies to overcome the physical, chemical, and biological barriers that limit the efficient and consistent delivery of drugs that are not readily absorbed following oral administration. The goal of this perspective is to describe these barriers to oral drug delivery in relation to some of the work currently being undertaken by the community of European scientists. This perspective is not intended to be inclusive and the author apologizes in advance to the many scientists working in Europe whose recent work was not included.

References

Jul 11, 2006·Current Opinion in Chemical Biology·John W DaviesJeremy L Jenkins
Jun 23, 2007·Current Drug Metabolism·A Bernkop-Schnürch, T Schmitz
May 16, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·N FotakiC Reppas
May 30, 2009·Current Opinion in Pharmacology·Michèle N Schulz, Roderick E Hubbard
Jul 17, 2010·International Journal of Pharmaceutics·Klaus Wening, Jörg Breitkreutz
Jul 27, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·G SharmaM N V Ravi Kumar
Jul 27, 2010·Trends in Pharmacological Sciences·Kathrin Bellmann-Sickert, Annette G Beck-Sickinger
Jul 27, 2010·International Journal of Pharmaceutics·Alessandra MaroniAndrea Gazzaniga
Aug 3, 2010·International Journal of Pharmaceutics·Laurence PlapiedAnne des Rieux
Aug 14, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Woei-Ping ChengDavid J Brayden
Aug 20, 2010·The American Journal of Clinical Nutrition·Robert E SteinertChristoph Beglinger
Aug 24, 2010·Drug Delivery·Valentina IannuccelliGilberto Coppi
Aug 31, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Camile B WoitiskiIsabel V Figueiredo
Sep 21, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Johannes ParmentierGert Fricker
Oct 5, 2010·International Journal of Pharmaceutics·Soravoot Rujivipat, Roland Bodmeier
Oct 5, 2010·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Said CharefJosé Courty
Oct 5, 2010·International Journal of Pharmaceutics·M J BareaR H Bridson
Oct 12, 2010·Biomaterials·Javed IqbalAndreas Bernkop-Schnürch
Oct 12, 2010·AAPS PharmSciTech·Annalisa DalmoroMatteo d'Amore
Oct 12, 2010·Expert Opinion on Biological Therapy·Kim HenriksenMorten Asser Karsdal
Oct 12, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hamid A MerchantSudaxshina Murdan
Oct 13, 2010·International Journal of Pharmaceutics·Friederike EisenächerKarsten Mäder
Oct 14, 2010·Current Medicinal Chemistry·Roman SinkAnamarija Zega
Oct 28, 2010·Expert Opinion on Drug Delivery·Grzegorz GarbaczWerner Weitschies
Nov 3, 2010·Drug Delivery·Gioconda MillottiAndreas Bernkop-Schnürch
Nov 3, 2010·The Journal of Pharmacy and Pharmacology·Thorsteinn Loftsson, Marcus E Brewster
Nov 3, 2010·The Journal of Pharmacy and Pharmacology·Anette MüllertzThomas Rades
Nov 10, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Esther WenkLorenz Meinel
Nov 13, 2010·International Journal of Pharmaceutics·Klaus Wening, Jörg Breitkreutz
Nov 13, 2010·Colloids and Surfaces. B, Biointerfaces·M J Santander-OrtegaJ L Ortega-Vinuesa
Nov 30, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·G MittalM N V Ravi Kumar
Dec 15, 2010·International Journal of Pharmaceutics·Johannes ParmentierGert Fricker
Dec 18, 2010·Nature Reviews. Drug Discovery·Elisabeth PerzbornFrank Misselwitz
Dec 21, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A AlmeidaC Vervaet
Jan 18, 2011·International Journal of Pharmaceutics·Mario GrassiGabriele Grassi
Feb 9, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Viralkumar F PatelMarc B Brown
Mar 3, 2011·International Journal of Clinical Pharmacy·Jonathan L Kaye
Mar 5, 2011·Advanced Drug Delivery Reviews·Vanessa HearndenMartin H Thornhill
Mar 8, 2011·Expert Opinion on Drug Delivery·Bert DevriendtEric Cox

❮ Previous
Next ❯

Citations

Aug 8, 2012·Physical Chemistry Chemical Physics : PCCP·Mohamed FatnassiBruno Alonso
Mar 5, 2013·Advanced Drug Delivery Reviews·Anne des RieuxVéronique Préat
Jun 26, 2014·ACS Combinatorial Science·Andreas KriegUlrich S Schubert
Oct 1, 2014·Expert Opinion on Drug Delivery·Simona De RobertisRuggero Bettini
Oct 6, 2012·Expert Opinion on Drug Delivery·Bo Xiao, Didier Merlin
Apr 30, 2013·Journal of Drug Targeting·Lin ZhangJie Sun
Jun 26, 2014·Expert Opinion on Drug Delivery·Xiuying LiMingshi Yang
Jan 6, 2016·Molecular Pharmaceutics·Nicholas G LamsonKathryn A Whitehead
Jan 10, 2016·Drug Delivery and Translational Research·Hussein O AmmarAlaa H Salama
Apr 14, 2016·Nanomedicine·Thanh Xuan NguyenQun Wang
Apr 20, 2016·International Journal of Pharmaceutics·Ramona BaumgartnerEva Roblegg
Mar 20, 2014·International Journal of Pharmaceutics·Paul L Goggin
Aug 3, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amrita BanerjeeSamir Mitragotri
Nov 29, 2016·Expert Opinion on Drug Delivery·Poornima RamburrunViness Pillay
May 5, 2017·Drugs·Nicoleta StoiceaSergio D Bergese
Jan 29, 2020·Archives of Pharmacal Research·Muhammad NaeemJin-Wook Yoo
Nov 7, 2019·Nature Biomedical Engineering·Nicholas G LamsonKathryn A Whitehead
Jun 9, 2018·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Ljiljana DjekicMarija Primorac

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
Anne des RieuxVéronique Préat
Journal of Controlled Release : Official Journal of the Controlled Release Society
Alexander T Florence
Journal of Controlled Release : Official Journal of the Controlled Release Society
Bert DevriendtEric Cox
© 2022 Meta ULC. All rights reserved