Oral drug self-administration in the home cage of mice: alcohol-heightened aggression and inhibition by the 5-HT1B agonist anpirtoline

Psychopharmacology
K A Miczek, R M De Almeida

Abstract

In order to model heightened aggression after alcohol consumption and to study the inhibitory influence of 5-HT1B receptors on drinking and fighting, an experimental procedure should enable self-administration of precise amounts of alcohol in a limited period of time before an aggressive confrontation. To design a new device that can reinforce operant responding by the delivery of sweet alcohol in the resident mouse home cage, where aggressive behavior toward an intruder can subsequently be examined, and to demonstrate inhibition of alcohol-heightened aggression by 5-HT1B receptor agonist treatment. Within one experimental session, all singly housed CFW male mice (n=26) performed a nose-poke response that was reinforced by 0.05 ml sucrose. Using the sucrose fading technique, eventually the mice consumed a 6% ethanol/4% sucrose solution after each fifth nose poke during daily 15-min experimental sessions. The number of ethanol reinforcements was adjusted so that 0.6, 1.0, 1.7, and 3.0-g/kg doses were consumed in 15 min or less. Assays confirmed blood alcohol levels at 68.1 mg/dl for intake of 1.0 g/kg. After consuming a specific dose of ethanol in the form of a fixed number of response-dependent deliveries, the response panel wa...Continue Reading

Citations

Apr 19, 2007·Psychopharmacology·Makoto BannaiKlaus A Miczek
Oct 24, 2007·Psychopharmacology·Elizabeth E Caldwell, Klaus A Miczek
May 17, 2012·Psychopharmacology·Emily L NewmanKlaus A Miczek
Nov 12, 2003·Hormones and Behavior·Silvana Chiavegatto, Randy J Nelson
Nov 12, 2003·Hormones and Behavior·Klaus A MiczekJoseph F De Bold
Feb 29, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sara FaccidomoKlaus A Miczek
May 3, 2005·Behavioural Pharmacology·S D McKenzie-QuirkK A Miczek
Feb 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Laura Bevilacqua, David Goldman
Sep 12, 2006·Addiction Biology·Christina S Barr, David Goldman
Jul 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Klaus A MiczekHerbert E Covington
Mar 22, 2006·Psychopharmacology·R M M De AlmeidaK A Miczek
Dec 1, 2006·Psychopharmacology·Annemoon M M van Erp, Klaus A Miczek
Aug 9, 2008·Psychopharmacology·Lígia Aline CentenaroRosa Maria Martins de Almeida
Sep 4, 2008·Psychopharmacology·Fábio C CruzKlaus A Miczek
Nov 3, 2009·Pharmacology, Biochemistry, and Behavior·Alessandra T PeanaMarco Diana
Apr 9, 2005·Annals of the New York Academy of Sciences·Klaus A MiczekJoseph F Debold
Apr 9, 2005·Annals of the New York Academy of Sciences·Berend Olivier
Jun 13, 2009·Alcoholism, Clinical and Experimental Research·Sheng-Yu LeeRu-Band Lu
Aug 19, 2015·Annals of the New York Academy of Sciences·Klaus A MiczekRosa M M de Almeida
Nov 29, 2005·European Journal of Pharmacology·Berend Olivier, Ruud van Oorschot
Nov 18, 2005·European Journal of Pharmacology·Pier Francesco FerrariKlaus A Miczek
May 6, 2015·Current Opinion in Behavioral Sciences·Klaus A MiczekRosa M M de Almeida
Sep 23, 2014·Psychopharmacology·Kevin J NormanKlaus A Miczek
Feb 18, 2006·Neuroscience and Biobehavioral Reviews·Randy J NelsonGregory E Demas
Jun 12, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Isabel M QuadrosKlaus A Miczek
Apr 15, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Nina K Popova
Feb 3, 2009·Alcoholism, Clinical and Experimental Research·Michael S McCloskeyEmil F Coccaro
Apr 8, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Tamlin S ConnerJonathan Covault
Jul 4, 2020·The European Journal of Neuroscience·Murilo S de AbreuAllan V Kalueff
Mar 11, 2003·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Thomas H WassinkNancy C Andreasen
Jul 30, 2015·Behavioural Pharmacology·Maria C Blanco-GandíaMaría A Aguilar
Nov 8, 2016·Frontiers in Endocrinology·Isabel Marian Hartmann QuadrosCristiane Aparecida Favoretto
Dec 6, 2005·European Journal of Pharmacology·Rosa M M de AlmeidaKlaus A Miczek

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