PMID: 6104844Jan 1, 1980Paper

Oral dyskinesia in brain-damaged rats withdrawn from a neuroleptic: implication for models of tardive dyskinesia

Psychopharmacology
R B Glassman, H N Glassman

Abstract

Rats with ablated frontal sensorimotor cortex and one with ablated sensorimotor connections to forebrain showed more vacuous chewing movements following 6-week chronic administration of a neuroleptic than did occipitally damaged rats or normal controls who were treated in the same way. The effect was still present 1 month after withdrawal. It was not clearly enhanced by subsequent treatments. Other behaviors (e.g., walking, rearing, or grooming) were not similarly affected by drug withdrawal. Additional results of terminal probes with amphetamine, apormorphine, and haloperidol are described, including movements labeled 'sham eating', observed only in frontal rats given apomorphine (AP). The results are interpreted in terms of a Jacksonina model of levels of brain organization; such a model may be applicable to tardive dyskinesia, seen in many schizophrenic patients who are maintained on neuroleptics for long periods.

References

Dec 1, 1975·The American Journal of Psychiatry·J M Davis
Feb 1, 1978·The American Journal of Psychiatry·A Carlsson
Jan 1, 1979·The American Journal of Psychiatry·G ChouinardJ N Nestoros
Nov 1, 1979·Psychopharmacology·C de MontignyL Annable
Apr 1, 1977·Journal of Comparative and Physiological Psychology·J Elbin, W Randall
Nov 24, 1976·Psychopharmacology·L M Gunne, S Bárány
Aug 1, 1976·Experimental Neurology·D Bieger, C H Hockman
Jul 1, 1976·Behavioral Science·R B Glassman
Feb 1, 1975·Journal of Comparative and Physiological Psychology·B Kolb, A J Nonneman
May 1, 1975·Experimental Neurology·A J Castro
Jan 1, 1973·The American Journal of Psychiatry·H L Klawans
Dec 1, 1973·Journal of Comparative and Physiological Psychology·M S Levine, J S Schwartzbaum
Nov 1, 1971·The Journal of Nervous and Mental Disease·D Shakow
Apr 1, 1967·Experimental and Molecular Pathology·Z GoriM Pollera
Jun 21, 1974·Science·S H SnyderD Greenberg

❮ Previous
Next ❯

Citations

Jan 1, 1989·Psychopharmacology·E D Levin, L M Gunne
Jan 1, 1990·Psychopharmacology·N M RupniakS D Iversen
Jan 1, 1990·Psychopharmacology·J D SalamoneR E Steinpreis
Apr 1, 1989·Pharmacology, Biochemistry, and Behavior·D WeinsteinG Ellison
Oct 1, 1993·Pharmacology, Biochemistry, and Behavior·R E Steinpreis, J D Salamone
Nov 1, 1994·Pharmacology, Biochemistry, and Behavior·H RosengartenA J Friedhoff
Jan 1, 1996·Pharmacology, Biochemistry, and Behavior·J Salamone, P Baskin
Feb 1, 1996·Pharmacology, Biochemistry, and Behavior·M F EganT M Hyde
Jul 1, 1996·Pharmacology, Biochemistry, and Behavior·E J Chesler, J D Salamone
Jul 1, 1997·Behavioural Brain Research·R E SteinpreisJ J Panos
Jan 1, 1999·Progress in Neurobiology·J D SalamoneA Nawab
May 1, 1985·Psychological Medicine·D CollertonP Britton
Mar 13, 2012·Behavioral and Brain Functions : BBF·Pierre J BlanchetDaniel Lévesque
Sep 30, 2014·Pharmacology, Biochemistry, and Behavior·Go KoganemaruYasushi Ishida
May 1, 1991·The International Journal of Neuroscience·R Sandyk, S R Kay
Mar 29, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Rebecka KlintenbergPer E Andrén
Jul 16, 2009·Pharmacology, Biochemistry, and Behavior·J TrevittC Larsen
Jul 1, 1986·Biological Psychiatry·C A KaufmannR J Wyatt
Dec 27, 1994·European Journal of Pharmacology·N Y Huang, R M Kostrzewa
Jan 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·J A Lieberman, R Reife

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here