PMID: 6539202Apr 1, 1984Paper

Oral (E)-5-(2-bromovinyl)-2'-deoxyuridine treatment of severe herpes zoster in cancer patients

European Journal of Cancer & Clinical Oncology
J Wildiers, E De Clercq

Abstract

BVDU [(E)-5-(2-bromovinyl)-2'-deoxyuridine] is a highly potent and selective anti-herpes drug. It is particularly active against Varicella zoster virus, as demonstrated in cell culture and animals (monkeys). BVDU has been administered orally, at a dose of 7.5 mg/kg/day for 5 days, to 20 patients with severe localised or disseminated Herpes zoster. All patients had a malignant disorder for which they had been given intensive chemo- or radiotherapy. Upon BVDU treatment a rapid cessation of the acute Herpes zoster episode was noted in all but one patient. In the majority of patients progression of the infection was arrested within 1 day of starting treatment. No toxic side-effects could be attributed to the drug at the dosage used.

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Citations

Jan 1, 1985·European Journal of Pediatrics·Y BenoitE De Clercq
Jul 1, 1985·Pflügers Archiv : European journal of physiology·M Le Hir, U C Dubach
Jan 1, 1994·Journal of Cancer Research and Clinical Oncology·H J KeizerE De Clercq
Apr 1, 1984·European Journal of Clinical Microbiology·E de Clercq
Jan 1, 1989·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·C AmeyeE de Clercq
Jan 1, 1984·Pharmacology & Therapeutics·E De Clercq, R T Walker
Aug 1, 1994·International Journal of Antimicrobial Agents·R SnoeckE De Clercq
Nov 4, 2000·Expert Opinion on Investigational Drugs·R SnoeckE De Clercq
Aug 21, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·M B MustafaS R Porter
Apr 29, 2008·Medicinal Research Reviews·Erik De Clercq
Jan 1, 1987·The Journal of Infection·B K Mandal
Sep 25, 2004·Medicinal Research Reviews·Erik De Clercq
Oct 23, 1997·Clinical Microbiology Reviews·E De Clercq
Jan 20, 1986·Life Sciences·E De Clercq, J J Cassiman
Oct 29, 2009·Journal of Medicinal Chemistry·Erik De Clercq
Feb 28, 2007·Bioorganic & Medicinal Chemistry·Nunzia CilibertiJan Balzarini

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