PMID: 15381720Sep 24, 2004Paper

Oral epithelial overexpression of IL-1alpha causes periodontal disease

Journal of Dental Research
S DayanT S Kupper

Abstract

Periodontal disease is a bacterial infection that results in inflammatory destruction of tissues that support the teeth, including connective tissue and bone. In this study, we report that transgenic mice that overexpress the 17-kDa form of IL-1alpha in the basal layer of oral mucosal epithelium develop a syndrome that possesses all of the cardinal features of periodontal disease, including epithelial proliferation and apical migration, loss of attachment, and destruction of cementum and alveolar bone. In this model, bacterial colonization and infection were not required, since levels of periodontal bacteria were equivalent in transgenic and wild-type mice, and continuous treatment with antibiotics from birth did not ameliorate the disease. Our findings therefore indicate that elevated levels of IL-1alpha in the oral micro-environment can mediate all of the clinical features of periodontal disease.

References

Aug 1, 1991·Journal of Clinical Periodontology·P StashenkoS S Socransky
May 1, 1980·Journal of Periodontology·J LindheM Listgarten
Mar 1, 1993·Journal of Clinical Periodontology·R A ReinhardtA C Allison
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·R W GrovesT S Kupper
Mar 1, 1996·The Journal of Biological Chemistry·E JimiT Koga
Aug 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R Pacifici
Mar 1, 1997·Annals of Periodontology·S S Socransky, A D Haffajee
Jul 1, 1997·Journal of Periodontal Research·G K Johnson, C C Organ
Jun 1, 1994·Periodontology 2000·A D Haffajee, S S Socransky
Jun 1, 1993·Periodontology 2000·K S Kornman, H Löe
Feb 26, 1999·Journal of Oral Science·Y MoriyaS Murai
Mar 11, 2000·Journal of Periodontology·M J McDevittK S Kornman
May 15, 2001·Journal of Clinical Periodontology·R NiedermanP Stashenko
Aug 27, 2002·The Journal of Infectious Diseases·Andrew J DelimaDana T Graves

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Citations

Jun 2, 2010·Nature Reviews. Microbiology·Richard P Darveau
Sep 4, 2008·Journal of Periodontology·Dana Graves
May 7, 2011·Journal of Oral Microbiology·Dana T GravesGustavo P Garlet
Oct 24, 2013·BioMed Research International·Rayyan A Kayal
Mar 8, 2016·Connective Tissue Research·Kevin A Tompkins
Jan 13, 2015·Virulence·George HajishengallisDana T Graves
Aug 1, 2014·Frontiers in Cellular and Infection Microbiology·Bob T RosierBastiaan P Krom
Jul 16, 2016·Archives of Oral Biology·Mazen K AlotaibiCharles F Shuler
Feb 22, 2005·Biochemical and Biophysical Research Communications·Ekaterini PantouliSreenivas Koka
Aug 22, 2007·Brazilian Oral Research·Marilene Issa FernandesCassiano Kuchenbecker Rosing
Dec 19, 2009·Periodontology 2000·Yen-Chun G LiuYen-Tung A Teng
Aug 18, 2010·Periodontology 2000·Sumita Jain, Richard P Darveau
Aug 18, 2010·Periodontology 2000·John J Taylor
Dec 8, 2010·Periodontology 2000·Alex B Berezow, Richard P Darveau
Jan 10, 2006·Periodontology 2000·P Mark Bartold, A Sampath Narayanan
Aug 8, 2015·Periodontology 2000·Sabine E Groeger, Joerg Meyle
Apr 18, 2013·The International Journal of Biological Markers·Liang HaoElizabeth L Y Ng
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hajime SasakiPhilip Stashenko
Nov 23, 2017·Frontiers in Immunology·Teun J de VriesElena A Nicu
Mar 11, 2021·Periodontology 2000·Ana M ChangRichard P Darveau
Sep 23, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Chia-Wen HsuChuen-Chyi Tseng

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