Oral exposure to BDE-209 modulates metastatic spread of melanoma in C57BL/6 mice inoculated with B16-F10 cells

Chemosphere
Patricia Manuitt BritoCiro Alberto de Oliveira Ribeiro

Abstract

Polybrominated diphenyl ethers (PBDEs) are brominated, persistent and bioaccumulative flame retardants widely used in the manufacture of plastic products. Decabromodiphenyl ether (BDE-209) is the most prevalent PBDE in the atmosphere and found in human blood, breast milk and umbilical cord. In vitro studies showed that BDE-209 interferes with murine melanoma cells (B16F10), modulating cell death rates, proliferation and migration, important events for cancer progression. In order to evaluate if BDE-209 modulates metastasis formation in murine models, C57BL/6 mice were exposed to BDE-209 (0.08, 0.8 and 8 μg⁄kg) via gavage (5-day intervals for 45 days) (9 doses in total). Then, mice were inoculated with melanoma cells (B16-F10) at caudal vein receiving 4 additional doses of BDE-209. At 20th day post-cell inoculation, blood, lung, liver, kidney and brain were sampled for hematological, biochemical and morphological analyses. The slightly higher levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the blood and pro-oxidant state in the liver of BDE-exposed mice indicated liver damage. Although the in vivo approach is for metastasis formation in the lung, they were unexpectedly observed in non-target orga...Continue Reading

References

Jun 1, 1985·Journal of Applied Toxicology : JAT·L D SwaimG C Jersey
Feb 24, 2000·The Journal of Pathology·F W OrrD M Nance
Nov 5, 2003·Environmental Health Perspectives·Arnold SchecterRobin Rosen
Nov 1, 2007·Environmental Science & Technology·Mark J La GuardiaEllen Harvey
Aug 5, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·F Filipak NetoC A Oliveira Ribeiro
Sep 2, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sara TagliaferriLucio G Costa
Oct 28, 2009·Human & Experimental Toxicology·Yukiko KawashiroChisato Mori
Apr 8, 2010·Free Radical Research·Geou-Yarh Liou, Peter Storz
Jul 24, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D BussolaroC A Oliveira Ribeiro
Sep 16, 2010·Free Radical Biology & Medicine·Simone ReuterBharat B Aggarwal
Jan 25, 2011·Nature Reviews. Cancer·Giulio FranciaRobert S Kerbel
Mar 12, 2011·Antioxidants & Redox Signaling·Valerio Chiurchiù, Mauro Maccarrone
Jul 21, 2011·International Journal of Toxicology·Mary C VagulaCharles F Nelatury
May 24, 2012·Mediators of Inflammation·Xianbao LiuDunjin Chen
Nov 6, 2012·Ageing Research Reviews·Venus SosaMatilde E LLeonart
Dec 5, 2012·Environmental Science and Pollution Research International·Wilfried SanchezJean-Marc Porcher
Nov 10, 2013·Nature Medicine·Daniela F Quail, Johanna A Joyce
Jul 15, 2015·Cancer Epidemiology·Carolina EspinaJoachim Schüz
Dec 18, 2015·Environmental Science and Pollution Research International·Vesna MilovanovicBiljana Antonijevic
Sep 8, 2017·Journal of Toxicology and Environmental Health. Part a·Lilian C PereiraDaniel J Dorta
Jun 21, 2018·ImmunoTargets and Therapy·Beatriz DominguesHelena Pópulo
Sep 21, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hui ZhiBi-Xian Mai
Aug 20, 2019·Seminars in Cancer Biology·Yiran LiangQifeng Yang

❮ Previous
Next ❯

Citations

Sep 19, 2021·Environmental Science and Pollution Research International·Gisleine Jarenko SteilFrancisco Filipak Neto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.