PMID: 8648777Jul 1, 1996Paper

Oral fleroxacin prophylaxis in transurethral surgery

The Journal of Urology
T C GasserR Frei


A prospective trial was done to test the efficacy of antimicrobial prophylaxis in patients undergoing transurethral surgery. A total of 75 adults with preoperatively sterile urine was randomized to receive either 400 mg. oral fleroxacin once daily or placebo as long as the catheter was in place. Urine cultures were obtained preoperatively and after removal of the catheter just before hospital discharge. Growth of 10(4)/ml. or more bacteria was considered a positive urine culture. Postoperative urinary tract infection rates were significantly lower in the fleroxacin group (3%) than in the placebo group (23%). Our study demonstrated the benefit of antimicrobial prophylaxis in preventing urinary tract infection after transurethral surgery, including resection of the prostate, in patients with sterile urine. The oral administration of 1 daily tablet of fleroxacin for the duration of catheterization is a safe, efficacious and clinically feasible regimen.


Apr 1, 1991·American Journal of Clinical Oncology·K MatsuokaK Eto
Jul 1, 1989·The Journal of Hospital Infection
Apr 23, 1987·The New England Journal of Medicine
Jul 1, 1987·Antimicrobial Agents and Chemotherapy·T C GasserP O Madsen
Jan 1, 1985·International Rehabilitation Medicine·D R Dunkerley
Oct 30, 1986·The New England Journal of Medicine·A B Kaiser
Jul 1, 1987·The British Journal of Surgery·C P Shearman
Feb 1, 1985·British Journal of Urology·W R Allan, A Kumar
Jan 1, 1973·The Journal of Infectious Diseases·N M SullivanS M Finegold
Apr 3, 1982·British Medical Journal·T B HargreaveJ C Gould
Jan 1, 1993·International Journal of Antimicrobial Agents·W CullmannA Braunsteiner


Sep 21, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Tetsuro MatsumotoJapanese Society of UTI Cooperative Study Group (Chairman; Tetsuro Matsumoto)
Jun 1, 2005·Journal of Chemotherapy·Shingo YamamotoOsamu Ogawa
Jan 6, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Minato YokoyamaKazunori Kihara
Jul 3, 2013·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yoshikazu TogoShingo Yamamoto
Aug 18, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Shingo YamamotoJapanese Research Group for UTI
Jul 5, 2013·The Cochrane Database of Systematic Reviews·Gail LusardiChristine Shaw

Related Concepts

Postoperative Complications
Drug or Chemical Tissue Distribution
Urethral Sphincters
Urinary Tract Infection
Urologic Diseases

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Laryngeal Neoplasms

Laryngeal Neoplasms occur in the Larynx and are typically associated with smoking and alcohol consumption. Discover the latest research on Laryngeal Neoplasms here.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
M Neale Weitzmann
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
T SatoK Watanabe
International Journal of Medical Sciences
Giorgio MoriFelice R Grassi
© 2021 Meta ULC. All rights reserved