PMID: 8648777Jul 1, 1996Paper

Oral fleroxacin prophylaxis in transurethral surgery

The Journal of Urology
T C GasserR Frei

Abstract

A prospective trial was done to test the efficacy of antimicrobial prophylaxis in patients undergoing transurethral surgery. A total of 75 adults with preoperatively sterile urine was randomized to receive either 400 mg. oral fleroxacin once daily or placebo as long as the catheter was in place. Urine cultures were obtained preoperatively and after removal of the catheter just before hospital discharge. Growth of 10(4)/ml. or more bacteria was considered a positive urine culture. Postoperative urinary tract infection rates were significantly lower in the fleroxacin group (3%) than in the placebo group (23%). Our study demonstrated the benefit of antimicrobial prophylaxis in preventing urinary tract infection after transurethral surgery, including resection of the prostate, in patients with sterile urine. The oral administration of 1 daily tablet of fleroxacin for the duration of catheterization is a safe, efficacious and clinically feasible regimen.

References

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Citations

Sep 21, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Tetsuro MatsumotoJapanese Society of UTI Cooperative Study Group (Chairman; Tetsuro Matsumoto)
Jun 1, 2005·Journal of Chemotherapy·Shingo YamamotoOsamu Ogawa
Jan 6, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Minato YokoyamaKazunori Kihara
Jul 3, 2013·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yoshikazu TogoShingo Yamamoto
Aug 18, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Shingo YamamotoJapanese Research Group for UTI
Jul 5, 2013·The Cochrane Database of Systematic Reviews·Gail LusardiChristine Shaw

Related Concepts

Microbicides
Postoperative Complications
Drug or Chemical Tissue Distribution
Urethral Sphincters
Urinary Tract Infection
Urine
Urologic Diseases
Quinodis

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