Oral fluid with three modes of collection and plasma methamphetamine and amphetamine enantiomer concentrations after controlled intranasal l-methamphetamine administration

Drug Testing and Analysis
Matthew N NewmeyerMarilyn A Huestis

Abstract

Methamphetamine is included in drug testing programmes due to its high abuse potential. d-Methamphetamine is a scheduled potent central nervous system stimulant, while l-methamphetamine is the unscheduled active ingredient in the over-the-counter nasal decongestant Vicks® VapoInhaler™. No data are available in oral fluid (OF) and few in plasma after controlled Vicks® VapoInhaler™ administration. We quantified methamphetamine and amphetamine enantiomers in OF collected with two different devices and plasma via a fully validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. Additionally, OF were analyzed with an on-site screening device. Sixteen participants received 7 Vicks® VapoInhaler™ doses according to manufacturer's recommendations. Specimens were collected before and up to 32 h after the first dose. No d-methamphetamine or d-amphetamine was detected in any sample. All participants had measurable OF l-methamphetamine with median maximum concentrations 14.8 and 16.1 μg/L in Quantisal™ and Oral-Eze® devices, respectively, after a median of 5 doses. One participant had measurable OF l-amphetamine with maximum concentrations 3.7 and 5.5 μg/L after 6 doses with the Quantisal™ and Oral-Eze® devices, respective...Continue Reading

References

Jan 20, 2006·Journal of Analytical Toxicology·John F Wyman, John T Cody
Oct 4, 2006·Clinical Pharmacology and Therapeutics·John MendelsonReese T Jones
Jul 23, 2008·BMC Clinical Pharmacology·John E MendelsonReese T Jones
Oct 16, 2008·Addiction·J Michael WalshJørg Mørland
Sep 12, 2009·Clinical Chemistry·Wendy M Bosker, Marilyn A Huestis
Mar 18, 2010·British Journal of Clinical Pharmacology·Linghui LiJohn Mendelson
Apr 5, 2014·Forensic Science International : Synergy·Frank MusshoffBurkhard Madea

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.