Sep 1, 1992

Oral gentamicin is not effective treatment for persistent diarrhea

Acta Paediatrica. Supplement
A V BartlettJ R Cruz

Abstract

We conducted a randomized, double-blind, placebo controlled clinical trial of oral gentamicin (10 milligrams/kilogram body weight/day for five days) in treatment of unselected cases of persistent diarrhea (duration 14-18 days at initiation of treatment) among 3-36-month-old children in a rural Guatemalan community. Following random assignment of each child to a treatment group, the appropriate dose of gentamicin or placebo was administered to the child three times daily by a study nurse; this nurse also identified the presence or absence of diarrhea on each day of treatment and for the next two days. Cure was defined as cessation of diarrhea during the five-day treatment period, sustained through at least the two days after completion of treatment. Among 92 evaluable cases who entered the clinical trial, there was essentially no difference in cure rate between gentamicin and placebo treatment groups (42% versus 43%). Enteroadherent strains of Escherichia coli were identified in 46% of children tested in this trial; no significant difference existed between treatment groups in frequency of isolation of this or any other enteropathogen. Among 40 children having successful duodenal cultures immediately prior to beginning treatment...Continue Reading

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References

Mentioned in this Paper

Gentamicins
Gentacycol
Duodenum
Diarrhea Persistent
Weighing Patient
Transcription Initiation
Gentamicin Measurement
Feces
Infantile Diarrhea
Evaluable Disease

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