Oral glucose challenge impairs skeletal muscle microvascular blood flow in healthy people

American Journal of Physiology. Endocrinology and Metabolism
Ryan D RussellMichelle A Keske

Abstract

Skeletal muscle microvascular (capillary) blood flow increases in the postprandial state or during insulin infusion due to dilation of precapillary arterioles to augment glucose disposal. This effect occurs independently of changes in large artery function. However, acute hyperglycemia impairs vascular function, causes insulin to vasoconstrict precapillary arterioles, and causes muscle insulin resistance in vivo. We hypothesized that acute hyperglycemia impairs postprandial muscle microvascular perfusion, without disrupting normal large artery hemodynamics, in healthy humans. Fifteen healthy people (5 F/10 M) underwent an oral glucose challenge (OGC, 50 g glucose) and a mixed-meal challenge (MMC) on two separate occasions (randomized, crossover design). At 1 h, both challenges produced a comparable increase (6-fold) in plasma insulin levels. However, the OGC produced a 1.5-fold higher increase in blood glucose compared with the MMC 1 h postingestion. Forearm muscle microvascular blood volume and flow (contrast-enhanced ultrasound) were increased during the MMC (1.3- and 1.9-fold from baseline, respectively, P < 0.05 for both) but decreased during the OGC (0.7- and 0.6-fold from baseline, respectively, P < 0.05 for both) despite...Continue Reading

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Citations

Dec 24, 2019·Clinical and Experimental Pharmacology & Physiology·Katherine M Roberts-ThomsonMichelle A Keske
Apr 15, 2020·American Journal of Physiology. Endocrinology and Metabolism·Lewan ParkerMichelle A Keske
Jul 9, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·K ReminyS Antoine-Jonville
Aug 23, 2020·Medicine and Science in Sports and Exercise·Andrew C BetikMichelle A Keske
Jan 12, 2021·Frontiers in Endocrinology·Jingyu WangBaocheng Chang
Mar 26, 2021·Journal of Applied Physiology·Yoanna M Ivanova, Denis P Blondin
Apr 4, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·James R BroatchLewan Parker
Oct 29, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Jason S AuMichaela C Devries

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Methods Mentioned

BETA
blood draws
enzyme-linked immunosorbent assay

Software Mentioned

SigmaStat

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