Oral glucose ingestion stimulates cholecystokinin release in normal subjects and patients with non-insulin-dependent diabetes mellitus

Metabolism: Clinical and Experimental
H HasegawaM Otsuki

Abstract

The role of glucose in the regulation of plasma cholecystokinin (CCK) level was investigated in healthy control subjects and patients with non-insulin-dependent diabetes mellitus (NIDDM). Plasma CCK concentration was determined by a specific and sensitive bioassay and by a highly sensitive and reliable double-antibody radioimmunoassay using OAL-656 as an antiserum. In control subjects, ingestion of Trelan G-75 (1,200 mOsm/L,225 mL), which is equivalent to 75 g glucose as metabolic products, caused a rapid and significant increase in plasma CCK bioactivity from 1.3 +/- 0.2 to a peak of 5.8 +/- 0.6 pmol/L and immunoreactive CCK concentration from 1.2 +/- 0.1 to 4.6 +/- 0.6 pmol/L. Ingestion of 75 g glucose in 225 mL water (33.3% solution) increased plasma CCK bioactivity to a similar degree to that observed following Trelan G-75 (peak response, 4.5 +/- 0.4 pmol/L). The same volume of 0.9% NaCl solution or water failed to increase plasma CCK concentration. A smaller dose of glucose (50 b/150 mL water) increased plasma CCK concentration, although the peak level (3.0 +/- 0.5 pmol/L) was less than that observed following 75 g glucose. In patients with NIDDM, Trelan G-75 ingestion increased CCK concentration, but the peak level was lo...Continue Reading

References

Mar 1, 1990·The Journal of Clinical Investigation·P HildebrandG A Stalder
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Citations

May 8, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Conan McCaulJames Gardiner
Apr 12, 2000·Journal of Gastroenterology and Hepatology·M Otsuki
Dec 6, 2006·American Journal of Veterinary Research·Mireia Lorenzo-Figueras, Alfred M Merritt
Sep 22, 2015·Journal of Clinical Biochemistry and Nutrition·Won-Young SongMasashi Mizuno
Jul 28, 2015·Pharmacology Research & Perspectives·O J MaceF Marshall
Feb 11, 2015·The Journal of Clinical Investigation·Arianna PsichasFiona M Gribble
Jun 23, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Fadi H MouradCamille F Nassar

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