Oral glutamine does not prevent bacterial translocation in rats subjected to intestinal obstruction and Escherichia coli challenge but reduces systemic bacteria spread

Nutrition
Paolo R O SalvalaggioAntonio C L Campos

Abstract

We investigated whether oral glutamine prevents bacterial translocation. Male Wistar rats were fed with isocaloric and isoproteic standard rat chow and randomly assigned to receive glutamine (GLN) or glycine administered through an orogastric tube at 1.5 g.kg(-1).d(-1) for 7 d. On day 8 of the study, the animals were anesthetized and intestinal obstruction was produced by ligature of the terminal ileum. A suspension containing 10(9) colony-forming units per milliliter of Escherichia coli ATCC 25992 was injected into the lumen of the ileum. Twenty-four hours later, blood was withdrawn, and mesenteric lymph nodes and fragments of spleen, liver, and lung were sent for microbiological analysis. Cultures were done on blood agar and MacConkey agar. Student's t test and analysis of variance between two proportions were used. P < 0.05 was considered significant. Rats in both groups lost body weight during the experiment (not significant). Mesenteric lymph node cultures were positive in both groups. The GLN group had a smaller percentage of E. coli in blood and organ cultures (65.45% versus 82.67% in the glycine group; P = 0.027). Positive cultures of blood, spleen, liver and lung also were higher on glycine group, although not signific...Continue Reading

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Citations

May 3, 2002·Nutrition·John MacFie, Clare McNaught
Apr 20, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Gerdien C MelisPaul A M van Leeuwen
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Feb 18, 2003·Current Opinion in Clinical Nutrition and Metabolic Care·David Kelly, Paul E Wischmeyer

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