PMID: 9650008Jul 3, 1998Paper

Oral guar gum treatment of intrahepatic cholestasis and pruritus in pregnant women: effects on serum cholestanol and other non-cholesterol sterols

European Journal of Clinical Investigation
H GyllingT A Miettinen

Abstract

Our aim was to investigate whether intestinal binding of bile acids by guar gum, a dietary fibre, relieves cholestasis and pruritus in intrahepatic cholestasis of pregnancy. Forty-eight pregnant women with cholestasis and pruritus were randomized double-blind to guar gum and placebo until the time of delivery, and 20 healthy pregnant women were used as control subjects. The pruritus score and serum bile acids, lipids and non-cholesterol sterols were measured at baseline, at least 2 weeks after treatment, just before delivery and up to 4 weeks after delivery. The increase in serum bile acids and worsening of pruritus were prevented by guar gum in relation to placebo (P < 0.05). Serum cholesterol was unchanged, but increased cholesterol precursor sterol values suggested that cholesterol synthesis was increased by guar gum. Serum cholestanol proportion, an indicator of cholestasis, was related to pruritus but was unaffected by guar gum. We conclude that in intrahepatic cholestasis of pregnancy and pruritus, guar gum treatment is beneficial in relieving pruritus, even although indicators of cholestasis are only partially reduced.

References

Sep 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·T A Miettinen, S Tarpila
Jul 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·M I UusitupaK Pyörälä
Mar 1, 1990·Atherosclerosis·P R TurnerB Lewis
Aug 31, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·T A Miettinen, S Tarpila
Oct 1, 1989·The American Journal of Clinical Nutrition·M J KallioT A Miettinen
Jan 1, 1986·The American Journal of Clinical Nutrition·R S Tilvis, T A Miettinen
Sep 15, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·T A Miettinen
May 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T A MiettinenJ Tuominen
Aug 22, 1996·The New England Journal of Medicine·T A Knox, L B Olans
Apr 1, 1996·Journal of Hepatology·H GyllingT A Miettinen
Jan 1, 1954·Acta Obstetricia Et Gynecologica Scandinavica·A SVANBORG

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Citations

Mar 12, 2003·Current Treatment Options in Gastroenterology·Frank LammertSiegfried Matern
Jun 14, 2001·The American Journal of Medicine·M H Pittler, E Ernst
May 7, 2009·World Journal of Gastroenterology : WJG·Victoria Geenes, Catherine Williamson
Aug 6, 2010·Obstetrics and Gynecology Clinics of North America·Bhuvan PathakRichard H Lee
Sep 11, 2012·Molecular Nutrition & Food Research·Marjukka KolehmainenRiitta Törrönen
Jan 22, 2002·Best Practice & Research. Clinical Obstetrics & Gynaecology·C Williamson
Oct 5, 2013·Best Practice & Research. Clinical Gastroenterology·Nwe Ni Than, James Neuberger
Apr 20, 2005·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M H PittlerE Ernst
Mar 12, 2003·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·D ScottE Borkowska
Jul 28, 2020·The Cochrane Database of Systematic Reviews·Kate F WalkerJim G Thornton
Jun 25, 2013·The Cochrane Database of Systematic Reviews·Vinita GurungJim G Thornton
Apr 9, 2001·Clinics in Liver Disease·E A Fagan

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