Abstract
Hybrid Verrucous Carcinoma is an uncommon tumour wherein Verrucous Carcinoma (VC) is coexisting with conventional Squamous Cell Carcinoma (SCC) within same maternal field. The heterogeneous nature, infrequency of occurrence and the difficulties associated with diagnosis and management of this tumor is discussed through a retrospective study. Patients of primary hybrid VC treated from Jan 2010 to May 2013 at a tertiary institute were analyzed on multivariate cox regression model. During the above mentioned period; 37 patients of hybrid VC were reported; 18(48.6 %) were male and 19(51.3 %) were female. Age ranged between 33 years to 78 years. Median follow up period was 32 months. T stage status and Stage grouping was not statistically significant for mortality (p value: 0.338). In the multivariate cox-regression model, the presence of second primary oral cancer was significantly associated with mortality, adjusted HR; 23.10 (95 % CI: 1.73, 307.65) (p = 0.017). Tumour staging is often unreliable in predicting prognosis of hybrid VC, occurrence of second primary oral cancer and recurrence appears to be significant factors effecting prognosis.
References
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·J FijuthJ P Le Bourgeois
Feb 1, 1992·The Annals of Otology, Rhinology, and Laryngology·B H HaugheyJ Harvey
Sep 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J S CooperJ D Cox
Jul 1, 1984·Archives of Otolaryngology·J E MedinaM A Luna
Sep 1, 1982·Head & Neck Surgery·J G BatsakisD H Rice
Jul 1, 1983·The Journal of Laryngology and Otology·G J Hordijk, J M de Jong
Oct 15, 1980·Cancer·M Shear, J J Pindborg
Apr 1, 1995·The Laryngoscope·M E Tharp, H Shidnia
Mar 15, 1995·Cancer·A S JonesT R Helliwell
Mar 1, 1995·Human Pathology·M J WorshamD L Van Dyke
Mar 4, 1998·Head & Neck·R M ByersP J Wolf
May 7, 1998·Head & Neck·L J OrvidasV J Suman
Jul 12, 2002·Head & Neck·Anthony Po Wing YuenWilliam Ignace Wei
Sep 1, 1953·Cancer·D P SLAUGHTERW SMEJKAL
Jun 2, 2006·Clinical Oral Investigations·Denise Tostes OliveiraLuiz Paulo Kowalski
Jul 16, 2008·Oral Oncology·Rohan R WalvekarAnil K D'Cruz
Oct 14, 2008·Oral Oncology·Julia Anne Woolgar, Asterios Triantafyllou
Apr 5, 2011·Oral Oncology·Ayotunde J FasunlaAndreas M Sesterhenn
Mar 6, 2012·Journal of Proteomics·Amit FulzeleSurekha M Zingde
Nov 6, 2012·Current Medical Research and Opinion·Jonessa Ann S Atienza, Constantin A Dasanu