Oral ibandronate in the management of postmenopausal osteoporosis: review of upper gastrointestinal safety

Maturitas
Sol EpsteinRalph C Schimmer

Abstract

Oral daily bisphosphonates carry a potential for gastrointestinal (GI) adverse events, which has been partly addressed by introducing once-weekly regimens. Nevertheless, the need to follow inconvenient dosing instructions every week could still hinder long-term compliance and therapeutic outcome. In addition, survey data indicates that many patients would prefer a once-monthly rather than once-weekly bisphosphonate dosing regimen. Ibandronate is a potent, nitrogen-containing bisphosphonate specifically developed for less frequent administration. In a pivotal study in postmenopausal osteoporosis, oral ibandronate, administered daily or with a between-dose interval of >2 months, demonstrated robust antifracture efficacy and an overall incidence of upper GI adverse events similar to placebo, even in patients at increased risk of such events. This and other clinical studies conducted in postmenopausal women demonstrate that oral ibandronate has an excellent upper GI safety profile.

References

Sep 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R C MühlbauerH Fleisch
Nov 1, 1994·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E G LufkinB L Riggs
Feb 27, 1995·The American Journal of Medicine·E Barrett-Connor
Jun 1, 1994·Drugs & Aging·R B Stewart, J W Cooper
Oct 3, 1996·The New England Journal of Medicine·P C de GroenK K Wang
Oct 12, 1996·Lancet·G Naylor, M H Davies
Aug 1, 1996·Endoscopy·D SorrentinoE Bartoli
Feb 1, 1997·Digestive Diseases and Sciences·M A BlankP N Smith
May 1, 1997·The American Journal of Medicine·J Levine, D Nelson
Dec 11, 1997·BMJ : British Medical Journal·R Kelly, H Taggart
Jan 20, 1998·Gastrointestinal Endoscopy·R B Cameron
Jan 28, 1998·Life Sciences·S N ElliottJ L Wallace
Jun 17, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E S SirisP J Bekker
Jul 1, 1998·Gastrointestinal Endoscopy·A RibeiroM E Stark
Sep 30, 1998·Digestive Diseases and Sciences·C P PeterS M Smith
Jun 4, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R E ColemanJ Kanis
Oct 20, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R G RussellM J Rogers
Nov 7, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H A PolsB Stych
Feb 9, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J ReginsterR Eastell
Mar 1, 2000·Archives of Internal Medicine·D C BauerD Freedholm
Jan 9, 2001·Archives of Internal Medicine·D Y Graham, H M Malaty
Feb 15, 2001·The New England Journal of Medicine·M R McClungUNKNOWN Hip Intervention Program Study Group
Jun 2, 2001·The New England Journal of Medicine·K L Sauder
Oct 5, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B J RiisC Christiansen
Feb 1, 2002·Aging : Clinical and Experimental Research·J D AdachiE Gomez-Panzani
Mar 13, 2002·Mayo Clinic Proceedings·Hugh TaggartKaren P Stevens
Aug 31, 2002·Endocrine Reviews·Ann CranneyUNKNOWN Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group
Oct 11, 2002·Mayo Clinic Proceedings·Byron Cryer, Douglas C Bauer
Nov 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R RizzoliUNKNOWN Alendronate Once-Weekly Study Group
Apr 1, 2003·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Miriam F DelaneyMeryl S LeBoff

❮ Previous
Next ❯

Citations

Mar 7, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S M CadaretteD H Solomon
Oct 18, 2006·Reviews in Endocrine & Metabolic Disorders·Sumapa Chaiamnuay, Kenneth G Saag
Jul 16, 2008·Expert Opinion on Drug Metabolism & Toxicology·Jean-Yves ReginsterOlivier Bruyère
Feb 19, 2009·Clinical Endocrinology·Bart L Clarke
Jul 6, 2013·Maturitas·Nicolás MendozaUNKNOWN Spanish Menopause Society
May 15, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elaine W YuMatthew T Drake
Nov 23, 2006·Arquivos brasileiros de endocrinologia e metabologia·Michael McClung
Jul 16, 2010·The Physician and Sportsmedicine·John A Sunyecz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
V BreuilE Legrand
Menopause : the Journal of the North American Menopause Society
Jane A CauleyMaryFran R Sowers
© 2021 Meta ULC. All rights reserved