PMID: 9422933Jan 10, 1998Paper

Oral immunisation as a strategy for enhancing corneal allograft survival

The British Journal of Ophthalmology
D MaJerry Y Niederkorn

Abstract

To determine optimal conditions for enhancing corneal allograft survival through oral administration of donor specific corneal cells. A mouse model of penetrating keratoplasty was used to evaluate the efficacy and optimal conditions for preventing immunological rejection of corneal allografts. C3H corneal grafts were transplanted orthotopically to CB6F1 recipients and represented mismatches at the entire major histocompatibility complex (MHC) and multiple minor histocompatibility loci. Tissue cultured C3H corneal epithelial and endothelial cells were administered orally to CB6F1 mice before or shortly after the application of orthotopic C3H corneal allografts. Cultured C3H corneal cells were conjugated with the non-toxic B subunit of cholera toxin as a means of preferentially inducing oral tolerance. Ten oral doses of donor cells administered before keratoplasty reduced the incidence of corneal graft rejection from 100% in untreated hosts to 54% in orally tolerised mice. Conjugation of cholera toxin to corneal cells significantly enhanced the efficacy of oral tolerance such that only 9% of the mice fed 10 doses of cholera toxin conjugated cells rejected their corneal grafts. Even a single oral inoculation of corneal cells conju...Continue Reading

References

Jan 1, 1991·Annual Review of Immunology·R M Steinman
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Jan 15, 1988·The Journal of Immunology : Official Journal of the American Association of Immunologists·P J Higgins, H L Weiner
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Mar 27, 1996·Transplantation·Y G HeJ Y Niederkorn

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Citations

Dec 4, 1998·Springer Seminars in Immunopathology·H L Weiner, Y Komagata
Jul 14, 2012·Immunotherapy·Ying WangZhiqiang Pan
Apr 16, 2011·Journal français d'ophtalmologie·E GuilbertV Borderie
Jun 19, 2007·Survey of Ophthalmology·Anita PandaSatya Priya
Jun 3, 2004·Nature Reviews. Immunology·Lloyd Mayer, Ling Shao
Sep 30, 2017·Current Ophthalmology Reports·Sayena JabbehdariAli R Djalilian

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