Oral immunization with a recombinant cysteine-rich section of the Entamoeba histolytica galactose-inhibitable lectin elicits an intestinal secretory immunoglobulin A response that has in vitro adherence inhibition activity.

Infection and Immunity
D E BevingJ I Ravdin

Abstract

The LC3-encoded 52-kDa recombinant protein includes amino acids 758 to 1134 of the 170-kDa subunit of the galactose-inhibitable lectin. Oral immunization of BALB/c mice with the LC3-encoded protein and cholera holotoxin induced an intestinal secretory immunoglobulin A (IgA) response (P < 0.01 compared with the control). There was a negative correlation (P = 0.001) between intestinal anti-LC3 IgA and serum IgA and IgG antibody responses. Intestinal secretions from immunized mice completely inhibited the galactose-specific adherence of axenic trophozoites ot Chinese hamster ovary cells (P < 0.01).

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Citations

Jul 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D Eichinger
Nov 3, 1998·Parasite Immunology·L Ortiz-OrtizD M Rosales-Borjas
Sep 23, 2003·Current Opinion in Infectious Diseases·William Stauffer, Jonathan I Ravdin
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Oct 23, 1997·Clinical Microbiology Reviews·S L Stanley

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