PMID: 3758076Sep 15, 1986Paper

Oral immunization with a synthetic peptide of cholera toxin B subunit. Obtention of neutralizing antibodies

European Journal of Biochemistry
A Guyon-GruazP Rivaille

Abstract

The ability of free synthetic fragments of the cholera toxin (CT), administered by parenteral or oral route, without adjuvant, to induce antibodies cross-reacting with CT was tested. Two peptides corresponding to the sequences 30-50 and 50-75 of the CT beta chain were selected and synthesized. Both free peptides, given intraperitoneally or orally, without adjuvant, elicited seric antibodies cross-reacting with CT. The anti-(P50-75) antibodies were able to neutralize the CT activity. Our results show that protection against a toxin at the systemic level can be obtained with a synthetic peptide even when administered by an oral route.

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Citations

May 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·I SchrannerU Lösch
Aug 1, 1991·Molecular Immunology·M Kazemi, R A Finkelstein
Jan 1, 1989·Biotechnology Advances·M A Schmidt
Mar 15, 1989·Biochemical and Biophysical Research Communications·A DelmasJ P Vaerman

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