Oral Immunotherapy for Egg Allergy: A Double-Blind Placebo-Controlled Study, with Postdesensitization Follow-Up

The Journal of Allergy and Clinical Immunology. in Practice
Lucia CaminitiGiovanni Passalacqua

Abstract

Oral immunotherapy (OIT) may be an effective treatment for food allergy in children. It is not clear if the OIT-induced effect is achieved by desensitization (transient state dependent on regular antigen exposure), or by tolerance (persistent condition where the ability to consume the food is retained even after a period of withdrawal). The aim of this study was to investigate the efficacy of OIT-egg desensitization in a double-blind placebo-controlled study, and to evaluate if, after desensitization, tolerance can be maintained. Children with egg allergy were randomized to OIT or placebo for 4 months. At the end of the controlled phase, a double-blind food challenge was repeated to confirm the achieved desensitization. Those subjects found to be desensitized were placed on an egg-containing diet for 6 months, followed by an egg avoidance phase for 3 months, when the food challenge was repeated to determine the maintained tolerance. A total of 31 children were randomized to OIT with dehydrated egg white (n = 17) or placebo (n = 14). Of the 17 active patients (1 dropout), 16 achieved desensitization and started the 6-month egg-containing diet. After 3-month of egg avoidance, 31% remained tolerant. In the control group, only 1 pa...Continue Reading

References

Aug 29, 2006·Lancet·Sabina IlliUNKNOWN Multicentre Allergy Study (MAS) group
Jan 9, 2007·The Journal of Allergy and Clinical Immunology·Ariana D BuchananA Wesley Burks
Jun 26, 2007·Allergy·A MuraroUNKNOWN EAACI Task Force on Anaphylaxis in Children
Oct 16, 2007·The Journal of Allergy and Clinical Immunology·Justin M SkripakRobert A Wood
Mar 18, 2009·Allergy and Asthma Proceedings·Lucia CaminitiGiovanni Battista Pajno
Jul 7, 2009·The Journal of Allergy and Clinical Immunology·Stacie M JonesA Wesley Burks
Nov 9, 2010·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Giovanni Battista PajnoGiovanni Passalacqua
Dec 28, 2010·Journal of the American Dietetic Association·Joshua A BoyceMatthew J Fenton
Mar 8, 2011·The Journal of Allergy and Clinical Immunology·Pooja VarshneyA Wesley Burks
Apr 5, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R García RodríguezF Guerra
Oct 12, 2011·Current Opinion in Allergy and Clinical Immunology·Giovanni B Pajno
Apr 3, 2012·The Journal of Allergy and Clinical Immunology·Gideon Lack
Jul 20, 2012·The New England Journal of Medicine·A Wesley BurksUNKNOWN Consortium of Food Allergy Research (CoFAR)
Aug 14, 2012·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Paolo MeglioElena Galli
Sep 11, 2012·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Iride Dello IaconoStefano Miceli Sopo
Apr 5, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Carmelo EscuderoMaría Dolores Ibáñez
Oct 15, 2013·Allergy·S S PanesarUNKNOWN EAACI Food Allergy and Anaphylaxis Group
Dec 21, 2013·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M Vazquez-OrtizA M Plaza
Mar 19, 2014·The Journal of Allergy and Clinical Immunology·Stacie M JonesChristophe Dupont
Jun 26, 2014·Pediatric Allergy, Immunology, and Pulmonology·Giovanni B PajnoGiuseppe Crisafulli

❮ Previous
Next ❯

Citations

Jan 18, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Noriyuki YanagidaMotohiro Ebisawa
Mar 5, 2016·Current Allergy and Asthma Reports·Robbie D Pesek, Stacie M Jones
Mar 1, 2016·The Journal of Allergy and Clinical Immunology·Stacie M JonesUNKNOWN Consortium of Food Allergy Research (CoFAR)
Dec 1, 2015·Immunology and Allergy Clinics of North America·Allison J BurbankRobert A Wood
Apr 10, 2016·The Journal of Allergy and Clinical Immunology·Robert A Wood
Mar 1, 2016·Current Allergy and Asthma Reports·Christina S K Yee, Rima Rachid
Jul 5, 2015·Current Allergy and Asthma Reports·David Chiang, M Cecilia Berin
May 13, 2015·Molecular Immunology·Pathum DhanapalaCenk Suphioglu
Jun 22, 2016·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Valérie Trendelenburg, Katharina Blümchen
Sep 18, 2016·Allergology International : Official Journal of the Japanese Society of Allergology·Aaron K Kobernick, A Wesley Burks
Aug 9, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Rachel L PetersKatrina J Allen
Jan 15, 2017·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Inmaculada Pérez-RangelMaría Dolores Ibáñez
Jan 4, 2017·International Archives of Allergy and Immunology·Noriyuki YanagidaMotohiro Ebisawa
Apr 1, 2017·Current Opinion in Allergy and Clinical Immunology·Ken-Ichi NagakuraMotohiro Ebisawa
Jun 7, 2017·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Claudio Rodríguez-CamejoAna Hernández
Jul 12, 2017·Human Vaccines & Immunotherapeutics·François GrahamPhilippe Bégin
Feb 23, 2018·Current Allergy and Asthma Reports·Christopher P ParrishJ Andrew Bird
Apr 5, 2018·Children·Sara Anvari, Katherine Anagnostou
Apr 21, 2018·The Cochrane Database of Systematic Reviews·Olga RomantsikMaria Grazia Calevo
Apr 27, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Liat NachshonArnon Elizur
Jul 10, 2018·Expert Review of Clinical Immunology·Stefania ArasiGiovanni Battista Pajno
May 31, 2018·International Archives of Allergy and Immunology·Akihiro MaetaKyoko Takahashi
Oct 13, 2016·Expert Opinion on Drug Delivery·Ana Brotons-CantoJuan M Irache
Sep 6, 2018·Human Vaccines & Immunotherapeutics·Manish Ramesh, Merhunisa Karagic
Nov 11, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·María Flora Martín-MuñozLuis Echeverría
Sep 1, 2018·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·María Flora Martín-MuñozLuis Echeverria
Feb 17, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Giovanni Battista PajnoStefania Arasi
Sep 21, 2017·Clinical Reviews in Allergy & Immunology·Christine Y Y WaiKa Hou Chu
Aug 24, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Makoto IraharaHiroshi Kido
Sep 6, 2019·Scandinavian Journal of Immunology·Célia CostaAna Todo-Bom
Jul 1, 2016·Current Opinion in Allergy and Clinical Immunology·Noriyuki YanagidaMotohiro Ebisawa
Jun 10, 2020·Critical Reviews in Biotechnology·Jeppe Madura LarsenKatrine Lindholm Bøgh
Mar 19, 2020·Bioscience Reports·Hiu Yan LamKwang Seok Ahn
Mar 25, 2020·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·P BéginM M Goetghebeur
Oct 21, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·A F WertN Schwerk
Jul 28, 2020·International Journal of Molecular Sciences·Dulashi Withanage Dona, Cenk Suphioglu
Nov 24, 2020·Frontiers in Immunology·Ann-Marie Malby SchoosWillem van de Veen
Jul 6, 2017·Allergologia et immunopathologia·A MartorellUNKNOWN Expert panel selected from members of the Spanish Societies of Pediatric Allergology, Asthma and Clinical Immunology (SEICAP
Feb 3, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Kati PalosuoMika J Mäkelä
Oct 8, 2020·The World Allergy Organization Journal·Kiyotake OguraMotohiro Ebisawa
Dec 19, 2017·Current Opinion in Immunology·J L McCarville, J S Ayres
May 4, 2021·Frontiers in Cellular and Infection Microbiology·Pei HanJin-Lyu Sun
Jul 27, 2021·Immunological Investigations·Vahid Ghobadi DanaSaba Arshi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.