Oral inflammation promotes oral squamous cell carcinoma invasion

Oncotarget
Cameron GoertzenMarco Magalhaes

Abstract

Oral squamous cell carcinoma (OSCC) represents 95% of oral malignancies and invasion, and metastasis underlies disease morbidity and mortality. We recently established a direct link between oral inflammation and cancer invasion by showing that neutrophils increase OSCC invasion through a tumor necrosis factor (TNFα)-dependent mechanism. The objective of this study was to characterize OSCC-associated inflammation and to determine the molecular mechanisms underlying inflammation-mediated OSCC invasion. Our results showed a significant increase in neutrophil infiltration, the neutrophil-to-lymphocyte ratio in the OSCC microenvironment and increased inflammatory markers, particularly TNFα in saliva. We performed next-generation sequencing of the TNFα-treated OSCC cells and showed marked overexpression of over 180 genes distributed among clusters related to neutrophil recruitment, invasion, and invadopodia. At the molecular level, TNFα treatment increased phosphoinositide 3-kinase (PI3K)-mediated invadopodia formation and matrix metalloproteinase (MMP)-dependent invasion. We show here that TNFα promotes a pro-inflammatory and pro-invasion phenotype leading to the recruitment and activation of inflammatory cells in a paracrine mechan...Continue Reading

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Citations

Jun 18, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Shan WangYumei Niu
Oct 2, 2020·The Journal of Pathology. Clinical Research·Aiman AliMarco Magalhaes
Oct 2, 2020·Metabolomics : Official Journal of the Metabolomic Society·Jéssica Gardone VitórioRicardo Santiago Gomez
Oct 26, 2018·Biological Procedures Online·Cameron GoertzenMarco Magalhaes
Jun 4, 2020·Cellular Oncology (Dordrecht)·Łukasz ZadkaPiotr Dzięgiel
Dec 8, 2020·European Journal of Dentistry·Neken PrasetyaningtyasNurina Febriyanti Ayuningtyas
Jan 8, 2021·PloS One·Flávia Alves VerzaDaniel Galera Bernabé
Mar 9, 2020·Archives of Oral Biology·Rafaely Ferreira SeveroFernanda Nedel
Jan 21, 2021·Scientific Reports·Elizabeth SalvoYi Ye
Nov 10, 2020·Frontiers in Immunology·Maksim DomnichJadwiga Jablonska
Mar 2, 2021·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Lakshmi Narayana MadaUrvashi Gaur
May 2, 2021·Scientific Reports·Shankargouda PatilAditi Chatterjee
Jul 3, 2021·International Journal of Molecular Sciences·Elena FerrariMarco Meleti
Sep 12, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shohei YoshimotoShuichi Hashimoto

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Datasets Mentioned

BETA
GM6001

Methods Mentioned

BETA
biopsies
confocal microscopy

Software Mentioned

plex Manager
Volocity
TOPHAT
GraphPad
BOWTIE
DAVID
CUFFLINKS
GeneCard
RNA V2 RSEM
BioCarta

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