Oral ingestion of streptococcus thermophilus diminishes severity of small intestinal mucositis in methotrexate treated rats

Cancer Biology & Therapy
Katie L TooleyRoss N Butler

Abstract

Currently, there are no available effective preventative or adjunctive agents to alleviate symptoms of chemotherapy-induced mucositis. This is compounded by the absence of a recognized and validated noninvasive biomarker to assess gut function. This study investigated the effects of orally ingested Streptococcus thermophilus (TH-4) on chemotherapy-induced small intestinal damage in rats using the noninvasive (13)C-sucrose breath test (SBT). Gastrointestinal damage was induced in 27 female dark agouti rats (148 +/- 1g) with MTX (1.5 mg/kg; i.m.). Rats received MTX or saline at 0 h; with daily treatment of: TH-4 at doses of 10(9) (high), 10(8) (low) cfu/mL, or skim milk (vehicle), 48 h pre and 96 h post-MTX. The noninvasive (13)C-sucrose breath test (SBT) was conducted at -24, 24 and 96 h post-MTX to monitor gut function. At sacrifice, small intestinal tissues were collected for determinations of sucrase activity, myeloperoxidase (MPO) activity and histological assessment. MTX + vehicle and MTX + low TH-4-treated rats produced significantly lower SBT and sucrase activity results compared to saline controls (p < 0.001). In contrast, MTX + high TH-4 treatment showed no significant differences in the SBT compared to saline controls,...Continue Reading

Citations

Aug 20, 2009·Cancer Chemotherapy and Pharmacology·K L TooleyR N Butler
Jan 24, 2007·Digestive Diseases and Sciences·Chad A MaugerGordon S Howarth
Mar 11, 2011·Critical Reviews in Food Science and Nutrition·Luca D PrisciandaroGordon S Howarth
Jun 5, 2007·Current Opinion in Oncology·Dorothy M Keefe
Sep 27, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Margot FijlstraWim J E Tissing
Jul 20, 2013·Scandinavian Journal of Gastroenterology·Hanru WangGordon S Howarth
Sep 29, 2009·International Journal of Medical Microbiology : IJMM·Tobias A Oelschlaeger
Oct 27, 2015·Environmental Toxicology and Pharmacology·Mohamed T KhayyalMona A El-Ghazaly
Aug 19, 2015·Nutrition and Cancer·Suzanne MashtoubGordon S Howarth
Aug 19, 2014·International Journal of Radiation Biology·Mona A El-GhazalyMohamed T Khayyal
Mar 31, 2015·Inflammatory Bowel Diseases·Andrzej WasilewskiJakub Fichna
Nov 8, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Margot FijlstraWim J E Tissing
Oct 18, 2016·Drug Discoveries & Therapeutics·Raja A H Kuchay
Dec 1, 2017·World Journal of Gastrointestinal Pathophysiology·Alexandra L WhittakerMichelle G Wirthensohn
Aug 30, 2018·International Journal of Cancer. Journal International Du Cancer·Kate R SecombeJoanne M Bowen
Aug 8, 2008·Current Opinion in Supportive and Palliative Care·Ross N Butler
Jan 3, 2013·The British Journal of Nutrition·Deniz Güney DumanBerrak Cağlayan Yeğen
May 2, 2013·Current Opinion in Supportive and Palliative Care·Rachel J Gibson
Nov 23, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·M FijlstraW J E Tissing
Aug 7, 2020·Research in Veterinary Science·María Lucía CorrealÁureo Evangelista Santana
Oct 14, 2021·Cancer·Sylvia L CrowderHeather S L Jim

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