Oral interferon-alpha treatment of mice with cryoglobulinemic glomerulonephritis

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Stephan SegererC E Alpers

Abstract

Cryoglobulins are associated with the development of a membranoproliferative glomerulonephritis, often referred to as cryoglobulinemic glomerulonephritis, particularly in the setting of hepatitis C virus infection. Parenteral interferon-alpha (IFN-alpha) commonly is used therapeutically in humans with cryoglobulinemic glomerulonephritis. We tested the therapeutic impact of oral IFN-alpha treatment in thymic stromal lymphopoietin (TSLP) transgenic mice, a strain that develops mixed cryoglobulinemia with glomerulonephritis closely resembling the disease that occurs in humans. A total of 41 female mice were treated for 21 days with daily ingestion of either 500 IU of Universal type I IFN or placebo. The studied groups included TSLP transgenic mice treated with IFN-alpha (n = 13), TSLP transgenic mice treated with placebo (n = 13), wild-type mice treated with IFN-alpha (n = 5), and wild-type mice treated with placebo (n = 10). A total of 39 mice completed the study; two TSLP transgenic mice treated with IFN-alpha died during the study period. Placebo-treated TSLP transgenic mice showed significantly increased mean glomerular tuft areas, mean glomerular areas occupied by macrophages, and mean cell numbers per glomerulus compared wit...Continue Reading

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Citations

Oct 2, 2009·American Journal of Physiology. Renal Physiology·Takamoto OhseStuart J Shankland
Dec 5, 2012·Apoptosis : an International Journal on Programmed Cell Death·Pietro E CippàThomas Fehr
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Jun 6, 2009·The American Journal of Pathology·Volker VielhauerStephan Segerer
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Feb 5, 2005·American Journal of Veterinary Research·Joseph M CumminsChad G Thompson

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