Oral iron supplementation for preventing or treating anaemia among children in malaria-endemic areas

The Cochrane Database of Systematic Reviews
Juliana U OjukwuMical Paul


Iron-deficiency anaemia is common during childhood. Iron supplementation has been claimed to increase the risk of malaria. To assess the effect of iron on malaria and deaths. We searched The Cochrane Library (2009, issue 1); MEDLINE; EMBASE; LILACS and metaRegister of Controlled Trials, all up to March 2009. We scanned references of included trials. Individually and cluster-randomized controlled trials conducted in hypoendemic to holoendemic malaria regions and including children < 18 years. We included trials comparing orally administered iron with or without folic acid vs. placebo or no treatment. Iron fortification was excluded. Antimalarials and/or antiparasitics could be administered to either group. Additional micronutrients could only be administered equally to both groups. The primary outcomes were malaria-related events and deaths. Secondary outcomes included haemoglobin, anaemia, other infections, growth, hospitalizations, and clinic visits. We assessed risk of bias using domain-based evaluation. Two authors independently selected studies and extracted data. We contacted authors for missing data. We assessed heterogeneity. We performed fixed-effect meta-analysis and presented random-effects results when heterogeneity ...Continue Reading


Jan 12, 2011·Annals of Hematology·Nils Milman
Feb 23, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Moses GwamakaPatrick E Duffy
Feb 25, 2011·Malaria Journal·Edward L SengaBernard J Brabin
Jul 17, 2012·Advances in Nutrition·Natasha SpottiswoodePatrick E Duffy
Oct 5, 2010·The American Journal of Tropical Medicine and Hygiene·Samuel N GaraTom D Thacher
Jun 10, 2014·Frontiers in Pharmacology·Natasha SpottiswoodeHal Drakesmith
Sep 9, 2011·The Cochrane Database of Systematic Reviews·Luz Maria De-RegilJuan Pablo Peña-Rosas
Feb 28, 2016·The Cochrane Database of Systematic Reviews·Ami NeubergerMical Paul
Feb 12, 2010·The Journal of Nutrition·Parminder S SuchdevRafael Flores
Jul 24, 2013·Evidence-based Child Health : a Cochrane Review Journal·Luz Maria De-RegilJuan Pablo Peña-Rosas
Apr 19, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G S TansarliM E Falagas
Aug 1, 2009·Journal of Evidence-based Medicine
Jan 29, 2013·Blood·Sant-Rayn PasrichaBeverley-Ann Biggs
Mar 4, 2011·The Journal of Nutrition·Rebecca J Stoltzfus
Feb 24, 2012·The Journal of Infectious Diseases·Lasse MarettyJørgen A L Kurtzhals
Jul 17, 2012·Advances in Nutrition·Rebecca J Stoltzfus
Apr 25, 2020·Pediatric Research·Sripriya Sundararajan, Heike Rabe
Dec 25, 2010·Ciência & saúde coletiva·Guilherme Loureiro WerneckThaise Gasser Gouvêa

Related Concepts

Iron Deficiency Anemia
Endemic Diseases
Clinical Trials

Related Feeds

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.


Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.


Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.