Oral iron supplements for children in malaria-endemic areas

The Cochrane Database of Systematic Reviews
Joseph OkebeMical Paul

Abstract

Iron-deficiency anaemia is common during childhood. Iron supplementation has been claimed to increase the risk of malaria. To assess the effect of iron on malaria and deaths. We searched The Cochrane Library, PUBMED, MEDLINE, LILACS; and trial registry databases, all up to June 2011. We scanned references of included trials. Individually and cluster randomized controlled trials conducted in hypoendemic to holoendemic malaria regions and including children below 18 years of age. We included trials comparing orally administered iron, iron with antimalarial treatment, or iron with folic acid versus placebo or no treatment. Iron fortification was excluded. Antihelminthics could be administered to either group. Additional micronutrients had to be administered equally to both groups. The primary outcomes were clinical (symptomatic) malaria, severe malaria, and death. Two authors independently selected the studies and extracted the data. We assessed heterogeneity and conducted subgroup analyses by the presence of anaemia at baseline, age, and malaria endemicity. We assessed risk of bias using domain-based evaluation. We performed a fixed-effect meta-analysis for all outcomes and random-effects meta-analysis for hematological outcomes....Continue Reading

Citations

Dec 21, 2013·PLoS Medicine·Roly D Gosling, Michelle S Hsiang
Aug 24, 2012·PloS One·Femkje A M JonkerTjalling Leenstra
Oct 23, 2013·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Lars G HemkensJohn P A Ioannidis
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Jul 17, 2012·Advances in Nutrition·Natasha SpottiswoodePatrick E Duffy
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May 14, 2014·The American Journal of Tropical Medicine and Hygiene·Joseph A Lewnard The Indigenous Health Adaptation To Climate Change Research Team
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Dec 14, 2011·The Cochrane Database of Systematic Reviews·Luz Maria De-RegilTherese Dowswell
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Jan 31, 2019·The Cochrane Database of Systematic Reviews·Ana C Fernández-Gaxiola, Luz Maria De-Regil
Feb 8, 2013·European Journal of Clinical Nutrition·H P S Sachdev, T Gera
Feb 28, 2016·The Cochrane Database of Systematic Reviews·Ami NeubergerMical Paul
Jul 2, 2019·The Cochrane Database of Systematic Reviews·Elizabeth Centeno TablanteJulia L Finkelstein
Aug 28, 2016·Nutrition Reviews·Violeta Moya-AlvarezMichel Cot
Nov 24, 2017·The Cochrane Database of Systematic Reviews·Luz Maria De-RegilJuan Pablo Peña-Rosas
Jun 11, 2020·Journal of Tropical Medicine·Arnaud TepaConstant Anatole Pieme

Related Concepts

Teens
Antimalarials
Folate
Iron
Malaria
Controlled Clinical Trials, Randomized
Parasitemia
Iron Deficiency Anemia
Endemic Diseases
Nutraceuticals

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