Oral Ketamine in Treatment-Resistant Depression: A Clinical Effectiveness Case Series

Journal of Clinical Psychopharmacology
Maryam I Al ShirawiJonathan Downar

Abstract

The aim of the study was to assess the effectiveness, tolerability, and safety of oral ketamine as an antidepressant treatment in adults with treatment-resistant depression. We reviewed retrospective data on 22 patients with treatment-resistant depression, who failed at least 3 adequate antidepressant treatment trials and 1 adequate trial of repetitive transcranial magnetic stimulation; subsequently, they received open-label treatment with oral ketamine, commenced at a dose of 50 mg every 3 days, titrated up by 25 mg every 3 days, according to response and tolerability. The primary outcome measure was the Beck Depression Inventory II, which was used to rate subjective mood improvement at baseline and then at each follow-up visit. Data about adverse effects related to ketamine and a self-harm risk assessment were also obtained. Over the course of treatment, 18% of the patients showed greater than 50% reduction in the Beck Depression Inventory II scores, 14% reported partial improvement in mood symptoms, while 45% had no response to ketamine and 23% showed a mild worsening in their depressive symptoms. The most frequent adverse effects were acute dissociation, dizziness, blurred vision, numbness and sedation. Neither serious adve...Continue Reading

References

Feb 25, 2000·Biological Psychiatry·R M BermanJ H Krystal
Aug 9, 2006·Archives of General Psychiatry·Carlos A ZarateHusseini K Manji
Apr 27, 2007·Psychopharmacology·Edward B PerryUNKNOWN Yale Ketamine Study Group
Nov 3, 2009·European Journal of Pain : EJP·Maren I BlonkFrank J P M Huygen
Jul 20, 2010·Journal of Palliative Medicine·Scott A Irwin, Alana Iglewicz
Sep 10, 2010·Current Medical Research and Opinion·Jasmina I IvanovaMichael D Stensland
Jul 23, 2011·Addiction·Celia J A MorganUNKNOWN Independent Scientific Committee on Drugs
Jan 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jeffrey BurgdorfJoseph R Moskal
Apr 12, 2013·CNS Neuroscience & Therapeutics·Georges Mion, Thierry Villevieille
Apr 30, 2013·European Journal of Anaesthesiology·Maria Celoni de Mello de GodoyJuliano Ferreira
Aug 29, 2013·The American Journal of Psychiatry·James W MurroughSanjay J Mathew
Jan 24, 2014·The Australian and New Zealand Journal of Psychiatry·Angelo De Gioannis, Diego De Leo
May 14, 2014·Biological Psychiatry·Kyle A B LapidusJames W Murrough
Jul 21, 2014·Psychopharmacology·Guillaume FondLaurent Boyer
Nov 8, 2014·International Journal of Psychiatry in Medicine·M L ZuccoliS Orengo
Nov 27, 2014·Current Neuropharmacology·Gianluca SerafiniMario Amore

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Citations

Sep 25, 2018·The British Journal of Psychiatry : the Journal of Mental Science·Yoav DomanyHaggai Sharon
Apr 17, 2018·Depression and Anxiety·Anne-Katharina DeisenhoferWolfgang Lutz
Apr 26, 2020·Journal of Clinical Psychopharmacology·Lutea A A de JongCornelis A J de Jong
May 18, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Briana K ChenChristine A Denny
Jun 15, 2019·The British Journal of Psychiatry : the Journal of Mental Science·Joshua Daniel Rosenblat
Feb 6, 2021·Translational Psychiatry·Adem T CanJim Lagopoulos
Nov 10, 2020·Focus : Journal of Life Long Learning in Psychiatry·William V BoboSagar V Parikh

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