Oral Kohki Tea and its protective effect against in vitro ischemic damage to the bladder

Neurourology and Urodynamics
R M LevinKen Aikawa

Abstract

Results of several studies indicate that ischemia/reperfusion (I/R) is an etiological factor in the contractile dysfunctions induced by partial bladder outlet obstruction in animal models. In support of this hypothesis, pretreatment of rabbits with Kohki Tea (Engelhardtia chrysolepis), a Japanese herbal drink very high in antioxidant activity, significantly reduced the contractile dysfunctions induced by partial outlet obstruction. The current study was designed to determine if pretreating rabbits with Kohki Tea could protect the bladder against the contractile damage induced by in vitro ischemia followed by re-oxygenation. Forty-eight New Zealand White rabbits were separated into two groups of 24; Group 1 was pretreated by oral gavage for 3 weeks with Kohki Tea and Group 2 received vehicle (water). Each rabbit was anesthetized with pentobarbital. The urinary bladder was rapidly removed and eight longitudinal muscle strips were cut from the bladder body. Each strip was mounted in a separate 15-ml bath containing Tyrode's solution with glucose (1 mg/ml) and maintained at 37 degrees C. All strips were equilibrated for 30 min with a gas mixture of 95% O2 and 5% CO2. At the end of this period of time, all strips were stimulated wit...Continue Reading

References

Jan 1, 1994·Neurourology and Urodynamics·R M LevinA J Wein
Jun 1, 1996·Bioscience, Biotechnology, and Biochemistry·H HaraguchiW H Chou
Sep 1, 1996·British Journal of Urology·A C Buck
Jan 1, 1997·Neurourology and Urodynamics·R M LevinP A Longhurst
Oct 26, 1999·Neurourology and Urodynamics·M A HassR M Levin
Feb 15, 2001·The Journal of Urology·A SchröderR M Levin
Feb 8, 2002·The Journal of Urology·Mohamed A GhafarRalph Buttyan
Apr 17, 2002·The Journal of Urology·Robert M LevinKenji Mizutani
Feb 13, 2003·Neurourology and Urodynamics·Robert M LevinPaul Chichester

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.