Oral L-arginine supplementation and faecal calprotectin levels in very low birth weight neonates

Journal of Perinatology : Official Journal of the California Perinatal Association
Elena PolycarpouD Kafetzis

Abstract

The objective of this study is to determine the potential effect of oral L-arginine supplementation on intestinal inflammation in very low birth weight (VLBW) neonates, as estimated by faecal calprotectin levels. The study enrolled 83 VLBW neonates with birth weight ≤1500 g and gestational age ≤34 weeks. In this double-blind study, 40 neonates received daily oral L-arginine supplementation of 1.5 mmol kg(-1) per day between the 3rd and 28th day of life, and 43 neonates placebo. Stool samples were collected on days 3, 14 and 28, and calprotectin was measured by enzyme-linked immunosorbent assay. Calprotectin values significantly decreased over time in both groups (P=0.032). No difference in faecal calprotectin values was recorded between neonates receiving arginine supplementation and neonates receiving placebo at days 3, 14 and 28. Faecal calprotectin values decrease with increasing postnatal age in VLBW infants, but this is not related to arginine supplementation.

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Citations

Jan 8, 2016·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Julia K PanczukDeborah L O'Connor
Jun 23, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Vasilios PergialiotisNikolaos Papantoniou
Apr 12, 2017·The Cochrane Database of Systematic Reviews·Prakeshkumar S ShahLauren E Kelly

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