Oral lactoferrin inhibits growth of established tumors and potentiates conventional chemotherapy

International Journal of Cancer. Journal International Du Cancer
Atul VaradhacharyFederica Pericle

Abstract

In this work, we investigated the anticancer activity of orally administered recombinant human lactoferrin (rhLF) alone and in combination with chemotherapy in tumor-bearing mice. rhLF inhibited the growth of squamous cell carcinoma (O12) tumors in T cell-immunocompromised nu/nu mice by 80% when administered at 1,000 mg/kg (2.9 g/m2) by oral gavage twice daily for 8 days (p < 0.001). Similar activity was observed in syngeneic, immunocompetent BALB/c mice, where orally administered rhLF (1,000 mg/kg, 2.9 g/m2 once daily) halted the growth of mammary adenocarcinoma TUBO. Oral rhLF (200 mg/kg, 0.57 g/m2) was also used alone and in combination with cis-platinum (5 mg/kg) to treat head-and-neck squamous cell carcinoma in a syngeneic murine model. Monotherapy with oral rhLF or cis-platinum caused 61% or 66% tumor growth inhibition over placebo, respectively. Mice receiving both therapies showed 79% growth inhibition, a statistically significant improvement over each drug alone. We then demonstrated that administration of oral rhLF (300 mg/kg, 0.86 g/m2) to tumor-bearing or naive mice resulted in (i) significantly increased production of IL-18 in the intestinal tract, (ii) systemic NK cell activation and (iii) circulating CD8+ T-cell ...Continue Reading

References

Mar 25, 1999·Acta Crystallographica. Section D, Biological Crystallography·X L SunE N Baker
Jun 8, 1999·Japanese Journal of Cancer Research : Gann·Y UshidaH Tsuda
Dec 22, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·L H Vorland
Oct 26, 2000·Japanese Journal of Cancer Research : Gann·W P WangH Tsuda
Mar 10, 2001·Biochemistry. Biokhimii︠a︡·T G KanyshkovaG A Nevinsky
Mar 15, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Franck BietLaurent Kremer
Mar 23, 2002·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Edward N BakerRichard D Kidd
Nov 9, 2002·Journal of Gastroenterology and Hepatology·Jun-Ichi TogawaHisahiko Sekihara
Dec 13, 2002·International Journal of Cancer. Journal International Du Cancer·Wataru HashimotoHideaki Tahara
Jun 18, 2003·Archives of Otolaryngology--head & Neck Surgery·David BrayBert W O'Malley

❮ Previous
Next ❯

Citations

Sep 30, 2005·Investigational New Drugs·Teresa G HayesAtul Varadhachary
Feb 25, 2009·Investigational New Drugs·Teresa G HayesAtul Varadhachary
Mar 13, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Min DengGuiyuan Li
Dec 19, 2008·Critical Reviews in Food Science and Nutrition·Lígia RodriguesHelena Lindmark Månsson
Apr 15, 2010·Journal of Toxicology and Environmental Health. Part a·Jian-Xiang LiJian Tong
Sep 21, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S RamalingamUNKNOWN FORTIS-M Study Investigators
Mar 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jeffrey S WolfBert W O'Malley
Apr 22, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Hiroyuki TsudaMasaaki Iigo
Jun 15, 2010·Molekuliarnaia genetika, mikrobiologiia i virusologiia·R I IakubovskaiaA L Gintsburg
Feb 6, 2014·Immunopharmacology and Immunotoxicology·Jonathan W RiessHeather A Wakelee
Aug 6, 2010·Expert Opinion on Biological Therapy·Ronan J Kelly, Giuseppe Giaccone
Mar 25, 2006·Expert Opinion on Pharmacotherapy·Lijuan Zhang, Timothy J Falla
Sep 20, 2006·Cancer Investigation·Philip E Shaheen, Ronald M Bukowski
May 3, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Raghunadharao DigumartiRajesh Malik
Sep 11, 2010·International Immunopharmacology·V Kumar, A Sharma
Jul 14, 2010·Biotechnology Advances·Celia ConesaLourdes Sánchez
Aug 25, 2009·Trends in Immunology·De YangJoost J Oppenheim
Feb 22, 2013·Critical Care Medicine·Russell McCulloh, Steven M Opal
Jul 16, 2008·The Journal of Surgical Research·Jose EngelmayerAtul Varadhachary
Jul 20, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yen-Wenn LiuWen-Chi Hou
Apr 28, 2006·The Journal of Pharmacy and Pharmacology·Eugene D Weinberg
Dec 19, 2006·Seminars in Cancer Biology·Maria Kost-Alimova, Stefan Imreh
Aug 25, 2015·Biochimica Et Biophysica Acta·Hassan Lemjabbar-AlaouiPetra Buchanan
Aug 13, 2005·Mutation Research·Kentaro TairaTomoe Negishi
Nov 14, 2015·Critical Reviews in Food Science and Nutrition·Blanca Hernández-Ledesma, Chia-Chien Hsieh
Jun 14, 2005·Medical Hypotheses·Michael P Sherman, Karel Petrak
Nov 3, 2005·Expert Opinion on Emerging Drugs·Philip E Shaheen, Ronald M Bukowski
Oct 23, 2004·Drug Metabolism and Pharmacokinetics·Hiroyuki TsudaMalcolm A Moore
Jul 6, 2011·Biochimica Et Biophysica Acta·Isui Abril García-MontoyaQuintín Rascón-Cruz
Mar 20, 2015·BioMed Research International·Chia-Chien HsiehJuliana María Leite Nobrega de Moura Bell
Nov 8, 2013·Human Vaccines & Immunotherapeutics·Hiroyuki SuzukiMitsukazu Gotoh
Apr 23, 2011·Veterinary Microbiology·M Atef YektaD Vanrompay
Dec 7, 2007·Protein Expression and Purification·Jie ZhangGuoxiang Cheng
Apr 22, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Antonius StevenBruce W Robinson
Aug 31, 2016·British Journal of Pharmacology·Arrigo F G CiceroAlessandro Colletti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

© 2022 Meta ULC. All rights reserved