Oral lesions as predictors of highly active antiretroviral therapy failure in Brazilian HIV-infected children

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
I D Miziara, R Weber

Abstract

Evaluate the accuracy of HIV-related oral lesions to predict immune and virologic failure on HIV-infected children in use of highly active antiretroviral therapy (HAART). Data for this cross-sectional analysis come from a longitudinal study being conducted through the HIV-AIDS Outpatient Unit, ENT Division, Hospital das Clinicas, Sao Paulo University Medical School. The study began in January 1990 and is still ongoing. The cut-off point for analyses purposes was December 2004. Subjects were 471 HIV-infected consecutive children attending the outpatient unit during this period, who enrolled regardless of medical or immunological status. The children have undertaken oral cavity examination, serum CD4(+) T-lymphocyte count, and, 271 of them, viral load measurement. Sensitivity, specificity, positive predictive value, negative predictive value and relative risk were calculated. Oral lesions had moderate sensitivity, high specificity and positive predictive value to predict immune failure. It had low sensitivity and positive predictive value, and high specificity to predict virologic failure. Oral manifestations of HIV can be important markers for immune suppression and for virologic failure, in Brazilian children undergoing HAART.

References

Nov 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·D MoniaciA Sinicco
Apr 1, 1994·Oral Surgery, Oral Medicine, and Oral Pathology·M GlickL M Salkin
Aug 1, 1993·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Sep 1, 1996·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·M D BeggI B Lamster
Mar 1, 1996·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A RavinaS Romagnani
May 1, 1998·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·V Ramirez-AmadorS Ponce-de-Leon
May 11, 1999·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·V MargiottaV Abbadessa
Sep 24, 1999·The Journal of the American Dental Association·L L Patton, D C Shugars
Mar 10, 2000·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·L L PattonJ J Eron
Apr 1, 2000·AIDS Patient Care and STDs·C A KozinetzM W Kline
Aug 18, 2000·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A M Schmidt-WesthausenP A Reichart
Dec 12, 2001·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·A R Tappuni, G J Fleming
Jan 17, 2002·The New England Journal of Medicine·S L GortmakerUNKNOWN Pediatric AIDS Clinical Trials Group Protocol 219 Team
Mar 19, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·J CampoA Bascones
Apr 10, 2002·Pesquisa odontológica brasileira = Brazilian oral research·Vera Lúcia Bosco, Esther Goldenberg Birman
Oct 11, 2003·The Pediatric Infectious Disease Journal·José Manuel SánchezAngel Nogales Espert
Dec 10, 2003·International Journal of Pediatric Otorhinolaryngology·Simon Hoare
Jan 27, 2004·Journal of Dental Research·D GreenspanJ S Greenspan
Feb 18, 2005·AIDS Patient Care and STDs·Luis Alberto Gaitán-CepedaAlejandro Ceballos-Salobreña
Jan 13, 2006·International Journal of Pediatric Otorhinolaryngology·Ivan D MiziaraRaimar Weber
May 5, 2006·Advances in Dental Research·S R FlintL MacPhail

❮ Previous
Next ❯

Citations

May 11, 2012·Journal of Investigative and Clinical Dentistry·Mahendra PereraPatrick Li
Apr 9, 2013·Revista Da Sociedade Brasileira De Medicina Tropical·Raquel dos Santos PinheiroGloria Fernanda Barbosa de Araujo Castro
Aug 27, 2014·International Journal of STD & AIDS·Luis Alberto Gaitán-CepedaNydia Castillo
Mar 29, 2011·Advances in Dental Research·V YengopalM Coogan
Mar 29, 2011·Advances in Dental Research·M McCulloughJ E Leigh
Apr 21, 2018·Viruses·Craig MillerSue VandeWoude
Jul 21, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Raquel dos Santos PinheiroGloria Fernanda Castro
Dec 31, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Daniella Ferraz CerqueiraGlória Fernanda Castro
Mar 6, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Wipawee NittayanantaNannapat Pruphetkaew
Oct 12, 2010·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·M S DuggalT Munyombwe
Nov 7, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Wipawee NittayanantaHutcha Sriplung
Mar 23, 2013·Oral Diseases·L L PattonK Ranganathan
Jun 14, 2013·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·P V BaghirathM M Ali
Dec 22, 2017·Ciência & saúde coletiva·Joyce Figueira de AraújoFernanda Ferreira Lopes
Feb 18, 2016·Oral Diseases·V YengopalM P Molete

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved