Oral lesions in organ transplant patients

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Robin A SeymourAnita Nolan

Abstract

Patients who have undergone organ transplantation can present with a variety of oral lesions that appear to be related either directly to their medication or arise as a consequence of drug-induced immunosuppression. Such lesions include hairy leukoplakia, an increased propensity to both fungal and viral infections and a high incidence of malignant change, especially lip cancer. Cyclosporin remains the immunosuppressant of choice in most transplant patients. Gingival overgrowth is the main unwanted oral effect associated with cyclosporin. Some 30% of dentate transplant experience this problem, which is further compounded by concomitant medication with a calcium channel blocker. This review appraises the various oral problems that can arise in this group of patients and emphasises the importance of regular oral screening and the establishment of links with the various transplant teams.

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Related Concepts

Calcium Channel Blockers
Immunosuppressive Agents
Mouth Diseases
Malignant Neoplasm of Mouth
Opportunistic Infections
Alveolar Pyorrhea
Organ Transplantation
Restasis
Leukoplakia, Hairy
Gingival Overgrowth

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