PMID: 6537892Feb 1, 1984Paper

Oral leukoplakia and malignant transformation. A follow-up study of 257 patients

Cancer
S SilvermanF Lozada

Abstract

Two hundred fifty-seven patients with oral leukoplakia were studied and followed for an average period of 7.2 years. All lesions were more than one cm in size and had been present and observed for a minimum of 6 months. Of the initial biopsies, 235 revealed a benign hyperkeratosis and 22 others contained some degree of epithelial dysplasia. Seventy-three percent of the patients used tobacco, with cigarette usage being the predominant form. Forty-five patients (17.5%) subsequently developed squamous carcinomas in the hyperkeratotic epithelial site in an average time of 8.1 years. Eight of these malignant transformations came from patients who originally had epithelial dysplasia. High risks for malignant transformation also included non-smoking patients, the clinical presence of erythroplasia (erythroleukoplakia), and a clinical verrucous-papillary hyperkeratotic pattern. Duration of the leukoplakia progressively increased the total number of malignant transformations, with the largest rate occurring in the second year. This study confirms that oral leukoplakia is a precancerous lesion and that certain characteristics indicate greater risks and warrant consideration of more aggressive management.

Associated Clinical Trials

Aug 31, 2010·Susan Mallery DDS, PhD, Susan Mallery DDS, PhD

References

Mar 1, 1977·Oral Surgery, Oral Medicine, and Oral Pathology·J J PindborgF S Mehta
Feb 1, 1977·Journal of Maxillofacial Surgery·J Bánóczy
Nov 1, 1977·Community Dentistry and Oral Epidemiology·R M BrowneG L Manning
Mar 21, 1978·British Dental Journal·I R KramerK W Lee
Dec 1, 1976·Oral Surgery, Oral Medicine, and Oral Pathology·J Bánóczy, A Csiba
Nov 1, 1966·Oral Surgery, Oral Medicine, and Oral Pathology·R A Cawson
Mar 1, 1972·Oral Surgery, Oral Medicine, and Oral Pathology·H H MincerK P Hopkins
Sep 1, 1972·The Journal of the American Dental Association·S Silverman, M Griffith
Apr 1, 1968·The Journal of the American Dental Association·S Silverman
Feb 1, 1981·Cancer Nursing·R Daeffler
Jan 1, 1980·Archives of Oral Biology·T M Arendorf, D M Walker
Nov 1, 1957·Cancer·E L WYNDERR M FELDMAN

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Citations

Mar 4, 2000·The Journal of Pathology·S Warnakulasuriya
Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·G Z QinP Lazarus
Jan 1, 1992·Journal of Cellular Biochemistry. Supplement·S E BennerW M Hittelman
Jan 1, 1993·Journal of Cellular Biochemistry. Supplement·J D CrissmanW Sakr
Jan 1, 1993·Journal of Cellular Biochemistry. Supplement·W N HittelmanW K Hong
Dec 1, 1994·Journal of Cellular Biochemistry·S C GirodG R Krueger
Oct 1, 1988·Gastrointestinal Radiology·D H FragerT C Beneventano
Aug 15, 2001·Folia Microbiologica·E DorkoK Lovásová
Nov 9, 2007·Mund-, Kiefer- und Gesichtschirurgie : MKG·Matthias NitscheUwe Eckelt
Feb 20, 2009·International Journal of Clinical Oncology·Hitoshi Shibuya
Jan 13, 2011·International Journal of Clinical Oncology·Teruo AmagasaNarikazu Uzawa
Jan 8, 2011·International Journal of Clinical Oncology·Teruo Amagasa
Jun 19, 2008·Wiener medizinische Wochenschrift·Michael Rasse
Jul 25, 2007·Cancer Causes & Control : CCC·Douglas E MorseEllen Eisenberg
Jan 15, 2003·Current Treatment Options in Oncology·Terry A DayRobert K Stuart
Mar 2, 2006·Current Oncology Reports·Ann GillenwaterRebecca Richards-Kortum
Mar 1, 2009·Head and Neck Pathology·Lewis Roy Eversole
Mar 21, 2012·Head and Neck Pathology·Andre W van ZylWillie F P van Heerden
Jul 16, 2014·Journal of Maxillofacial and Oral Surgery·Aruna TambuwalaAatif Sayed
Jul 1, 1989·Oral Surgery, Oral Medicine, and Oral Pathology·J G LovasA K ElGeneidy
Jan 1, 1993·European Journal of Cancer. Part B, Oral Oncology·F ChiesaS Zurrida
Apr 1, 1993·European Journal of Cancer. Part B, Oral Oncology·L R Eversole, J P Sapp
Jan 1, 1995·European Journal of Cancer. Part B, Oral Oncology·C Scully
Nov 1, 1994·European Journal of Cancer. Part B, Oral Oncology·S C GirodG R Krueger
Nov 1, 1995·European Journal of Cancer. Part B, Oral Oncology·K P Schepman, I van der Waal
Jul 1, 1996·European Journal of Cancer. Part B, Oral Oncology·H NielsenP Holmstrup
Jun 7, 2005·Oral Oncology·Drore Eisen, Stephen Frist

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