Oral leukoplakia-to treat or not to treat

Oral Diseases
P Holmstrup, E Dabelsteen

Abstract

Various treatment modalities have been described for reducing or eliminating malignant development of oral leukoplakia, but no treatment has gained universal approval due to lack of randomized clinical studies. At present, it is uncertain whether we can do harm to the patients by treating or by not treating them. An essential aspect is the observation of cancer development even after surgical removal of the clinical lesions. Inadequate resection of the lesions or field cancerization may account for this phenomenon. Another challenge is whether surgical removal of the lesions in fact is associated with a cancer promotional effect resulting in increased risk of cancer. Moreover, unidentified existing cancer in non-suspicious oral leukoplakias may for diagnostic purposes imply that surgical removal is recommendable as well as serial section of all excised tissue. Intensive follow-up programmes for leukoplakias are important, independent of surgical intervention.

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Citations

Dec 23, 2016·Lasers in Medical Science·Flávia Cristina Perillo RosinLuciana Corrêa
Feb 27, 2018·Oral Diseases·P Holmstrup
Jan 22, 2021·Acta Odontologica Scandinavica·Magdalena KorytowskaBengt Hasséus
Nov 18, 2018·Journal of the American Academy of Dermatology·Mayra B C MaymoneNeelam A Vashi
Apr 5, 2021·Clinical Oral Investigations·Shalini R GuptaKalaivani Mani
Oct 27, 2018·Dental Materials : Official Publication of the Academy of Dental Materials·Pauline MittermüllerWolfgang Buchalla
Aug 18, 2021·Laryngoscope Investigative Otolaryngology·Hunter ArchibaldFrank G Ondrey
Jul 2, 2021·Cancer Prevention Research·Christina McCordGrace Bradley
Jul 30, 2021·Oral Diseases·Alexander Ross Kerr, Giovanni Lodi
Nov 24, 2021·Clinical Oral Investigations·Shalini R GuptaKalaivani Mani

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