Oral lichen planus - Differential diagnoses, serum autoantibodies, hematinic deficiencies, and management

Journal of the Formosan Medical Association = Taiwan Yi Zhi
Chun-Pin ChiangAndy Sun

Abstract

Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease that occurs more frequently in middle-aged and elderly female patients. Previous studies indicate that OLP is a T-cell dysfunction-induced localized autoimmune disease. Clinically, six types of OLP, namely reticular, papular, plaque-like, atrophic/erosive, ulcerative, and bullous types, can be identified. OLP more commonly affects buccal mucosa, tongue, and gingiva. It always has a bilateral and symmetric distribution of the oral lesions. Plaque-like and atrophic/erosive OLP may be misdiagnosed as oral leukoplakia and oral erythroleukoplakia, respectively. Our previous study found serum autoantibodies in 195 (60.9%) of the 320 OLP patients. Specific serum anti-nuclear, anti-smooth muscle, anti-mitochondrial, gastric parietal cell, thyroglobulin, and thyroid microsomal autoantibodies are present in 28.1%, 8.4%, 1.6%, 26.3%, 21.3%, and 24.4% of 320 OLP patients, respectively. Furthermore, we also discovered that 21.9%, 13.6%, 7.1%, 0.3%, and 14.8% of 352 OLP patients have hemoglobin, iron, vitamin B12, and folic acid deficiencies, and abnormally high serum homocysteine level, respectively. Therefore, it is very important to examine the serum autoantibody, hem...Continue Reading

Citations

Oct 26, 2018·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·Aya Khamis KhamisMohamed Hamdy Helal
Apr 22, 2019·Experimental Dermatology·Jing ShanJuanyong Xu
Mar 28, 2020·Scientific Reports·César RiveraWilfredo Alejandro González-Arriagada
Jul 7, 2019·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chun-Pin ChiangAndy Sun
Jul 22, 2019·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chun-Pin ChiangAndy Sun
Sep 6, 2020·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Meng-Ling ChiangAndy Sun
Mar 2, 2021·Dental Clinics of North America·Annetty P Soto, Sarah L Meyer
Mar 13, 2021·BioMed Research International·Fahimeh Rezazadeh, Sara Haghighat
Mar 25, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Meng-Ling ChiangChun-Pin Chiang
Apr 4, 2021·Journal of Cosmetic Dermatology·Ahmet YukkaldıranMustafa Aksoy
Nov 19, 2019·International Journal of Biological Macromolecules·Jing ZhangGang Zhou
Sep 18, 2020·Journal of Oral Biology and Craniofacial Research·Shantala R NaikAnjani Kumar Shukla

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