Oral magnesium supplementation improves insulin sensitivity in non-diabetic subjects with insulin resistance. A double-blind placebo-controlled randomized trial

Diabetes & Metabolism
Fernando Guerrero-RomeroMartha Rodríguez-Morán

Abstract

Although hypomagnesemia reduces insulin sensitivity, benefits of magnesium supplementation to non-diabetic insulin resistant subjects has not been established. Our purpose was to determine whether oral magnesium supplementation with magnesium chloride (MgCl2) 2.5 g daily modify insulin sensitivity in non-diabetic subjects. This study was a 3 months randomized double-blind placebo-controlled trial. Apparently healthy subjects were eligible to participate if they had insulin resistance (HOMA-IR index equal or greater than 3.0) and hypomagnesemia (Serum magnesium levels equal or lower than 0.74 mmol/l). Subjects were randomized to receive either, MgCl2 2.5 g daily or placebo by 3-months. At baseline there were not significant anthropometric or laboratory differences between both groups. At ending of the study, magnesium-supplemented subjects significantly increased their serum magnesium levels (0.61 +/- 0.08 to 0.81 +/- 0.08 mmol/l, p<0.0001) and reduced HOMA-IR index (4.6 +/- 2.8 to 2.6 +/- 1.1, p<0.0001), whereas control subjects did not (0.62 +/- 0.08 to 0.61 +/- 0.08 mmol/l, p=0.063 and 5.2 +/- 1.9 to 5.3 +/- 2.9, p=0.087). Oral magnesium supplementation improves insulin sensitivity in hypomagnesemic non-diabetic subjects. Cli...Continue Reading

References

Sep 26, 1991·The New England Journal of Medicine·D E Moller, J S Flier

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Citations

Jul 11, 2012·Biological Trace Element Research·Ju-Hye Chung, Keun-Sang Yum
Jun 1, 2005·Archives of Medical Research·Fernando Guerrero-Romero, Martha Rodríguez-Morán
Sep 20, 2012·The British Journal of Nutrition·Hui ZuoAkhtar Hussain
Feb 10, 2012·European Journal of Clinical Nutrition·L KassL Carpenter
Jan 19, 2007·Journal of the American College of Nutrition·Marcella E RumawasPaul F Jacques
Aug 4, 2010·Journal of the American College of Nutrition·Kyoko KiriiUNKNOWN JACC Study Group
Mar 2, 2006·Critical Reviews in Food Science and Nutrition·Jane V Higdon, Balz Frei
Feb 16, 2008·Critical Reviews in Food Science and Nutrition·Stella Lucia Volpe
Aug 2, 2007·American Journal of Therapeutics·Mario BarbagalloLawrence M Resnick
Nov 26, 2010·The American Journal of Clinical Nutrition·Stephanie E ChiuveChristine M Albert
Jun 10, 2011·The Journal of Nutrition·Marcia C C de Oliveira OttoJennifer A Nettleton
Mar 29, 2014·Biological Trace Element Research·Whan-Seok ChoiJu-Hye Chung
Mar 13, 2012·Annual Review of Nutrition·William B Weglicki
Mar 11, 2015·Journal of Clinical and Experimental Hepatology·Chantal Bémeur, Roger F Butterworth
Jun 24, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Faranak SharifiSaideh Mazloomzadeh
Feb 28, 2016·Nutrition·Nizal SarrafzadeganAmin Salehi-Abargouei
Feb 8, 2011·Diabetes & Metabolism·A Räkel, A D Karelis
Dec 17, 2008·Nutrition Research·Angelos A EvangelopoulosPeter C Avgerinos
Sep 12, 2007·Archives of Medical Research·Lázaro Barragan-RodríguezFernando Guerrero-Romero
Jul 25, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S Van LaeckeR Vanholder
Apr 28, 2009·Pharmazie in unserer Zeit·Klaus Eder
Aug 8, 2007·Journal of the Cardiometabolic Syndrome·Mario Barbagallo, Ligia J Dominguez
Aug 8, 2007·Journal of the Cardiometabolic Syndrome·Ka HeYouguo Chen
May 21, 2008·European Journal of Clinical Investigation·F Guerrero-RomeroN Wacher
Apr 14, 2011·Diabetes/metabolism Research and Reviews·Martha Rodríguez-Morán, Fernando Guerrero-Romero
Feb 11, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Robert P KauffmanV Daniel Castracane
Jan 19, 2011·European Journal of Clinical Investigation·Fernando Guerrero-Romero, Martha Rodríguez-Morán
Jul 1, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·D T DibabaK He
Dec 8, 2011·Journal of Pediatric Endocrinology & Metabolism : JPEM·Nurullah CelikAyse Esra Yilmaz
Jul 1, 2006·Archives of Biochemistry and Biophysics·Mario Barbagallo, Ligia J Dominguez
Jun 10, 2006·Archives of Biochemistry and Biophysics·Bruno Sontia, Rhian M Touyz
Apr 28, 2005·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J I MannUNKNOWN Diabetes and Nutrition Study Group (DNSG) of the European Association

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