Oral Management for Pediatric Lyme Meningitis

Journal of the Pediatric Infectious Diseases Society
Santiago M C LopezAndrew J Nowalk

Abstract

Guidelines for pediatric Lyme meningitis recommend treatment with parenteral therapy [1, 2]. Adult studies suggest that Lyme meningitis can be successfully treated with oral therapy. Our objective was to evaluate the clinical response, side effects and outcome of oral therapy for Lyme meningitis in the pediatric population compared with parenteral therapy in an area endemic for Lyme disease. We conducted a case series chart review from January 2012 to May 2017 of pediatrics patient diagnosed and treated for Lyme meningitis. We recorded clinical presentation, laboratory values, antimicrobial therapy and follow up after therapy to compare the efficacy of oral versus parenteral route of therapy. We identified 38 patients diagnosed with Lyme meningitis. Thirty-two patients were discharge with exclusively oral therapy with: doxycycline and amoxicillin. We had only 2 patients developed potential adverse effects from oral doxycycline therapy. All patients treated with oral antibiotics had resolution of symptoms on follow up appointments. Oral therapy for Lyme meningitis yields no serious adverse events, was well tolerated and showed resolution of symptoms.

References

Dec 19, 2002·The Pediatric Infectious Disease Journal·Carita ThorstrandMargareta Eriksson
Mar 26, 2003·European Journal of Pediatrics·David TuerlinckxGeorges de Bilderling
Oct 10, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gary P WormserRobert B Nadelman
Jun 6, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allen C SteereVijay K Sikand
Dec 23, 2011·The Pediatric Infectious Disease Journal·Angela BarrierC Buddy Creech
Jan 8, 2016·Journal of Neurology·Sriram RamgopalAndrew Nowalk

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Citations

Sep 24, 2021·Hospital Pediatrics·Kelly M RoelfUNKNOWN for Pedi Lyme Net

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