Oral medications including clomiphene citrate or aromatase inhibitors with gonadotropins for controlled ovarian stimulation in women undergoing in vitro fertilisation

The Cochrane Database of Systematic Reviews
Mohan S KamathAhmed Gibreel

Abstract

Gonadotropins are the most commonly used medications for controlled ovarian stimulation in in vitro fertilisation (IVF). However, they are expensive and invasive, and are associated with the risk of ovarian hyperstimulation syndrome (OHSS). Recent calls for more patient-friendly regimens have led to growing interest in the use of clomiphene citrate (CC) and aromatase inhibitors with or without gonadotropins to reduce the burden of hormonal injections. It is currently unknown whether regimens using CC or aromatase inhibitors such as letrozole (Ltz) are as effective as gonadotropins alone. To determine the effectiveness and safety of regimens including oral induction medication (such as clomiphene citrate or letrozole) versus gonadotropin-only regimens for controlled ovarian stimulation in IVF or intracytoplasmic sperm injection (ICSI) treatment. We searched the following databases: Cochrane Gynaecology and Fertility Group Specialised Register (searched January 2017), the Cochrane Central Register of Controlled Trials (CENTRAL CRSO), MEDLINE (1946 to January 2017), Embase (1980 to January 2017), and reference lists of relevant articles. We also searched trials registries ClinicalTrials.gov (clinicaltrials.gov/) and the World Heal...Continue Reading

References

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Citations

Oct 6, 2020·Frontiers in Endocrinology·Kristine LøsslClaus Yding Andersen
Aug 18, 2018·The Cochrane Database of Systematic Reviews·Cindy Farquhar, Jane Marjoribanks
Sep 17, 2020·Diagnostics·Polina GiannelouKonstantinos Sfakianoudis
Feb 23, 2020·Current Drug Targets·Esteban FerreiroElkin Muñoz
Jul 6, 2021·Frontiers in Endocrinology·Ai-Min YangGui-Min Hao

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