PMID: 3760277Sep 1, 1986Paper

Oral methotrexate therapy for chronic rheumatoid arthritis ulcerations

Journal of the American Academy of Dermatology
L R EspinozaB F Germain

Abstract

Eight patients with long-standing rheumatoid arthritis and cutaneous vasculitis ulcerations resistant to conventional therapy were treated successfully with a low-dose intermittent regimen of oral methotrexate. Objective clinical response was prompt and complete resolution was observed at about 12 weeks of therapy. The drug was well tolerated. Mild gastrointestinal side effects were the most common untoward reaction. We conclude that methotrexate therapy is an effective agent for some of the extraarticular manifestations of rheumatoid arthritis including vasculitis, and further clinical evaluation should be a consideration.

References

Jan 1, 1976·Arthritis and Rheumatism·D L ConnF C McDuffie
Sep 1, 1985·The Journal of Clinical Investigation·B A ChabnerJ Jolivet
Nov 1, 1967·Annals of the Rheumatic Diseases·M Wilkinson, W N Torrance
Sep 1, 1980·Clinical Immunology and Immunopathology·L R EspinozaC K Osterland
Jan 1, 1955·Acta Rheumatologica Scandinavica·V A LAINE, K J VAINIO

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Citations

Feb 1, 1993·British Journal of Clinical Pharmacology·H G Taylor, A Samanta
Nov 1, 1992·Arthritis and Rheumatism·G S HoffmanA S Fauci
Sep 1, 1989·Clinical Rheumatology·M E JeurissenL B van de Putte
Sep 16, 2010·Current Rheumatology Reports·Christie M Bartels, Alan J Bridges
Sep 10, 2011·Current Rheumatology Reports·Antonio Iglesias-GamarraLuis R Espinoza
May 1, 1997·Baillière's Clinical Rheumatology·F C Breedveld
Feb 9, 2012·The Australasian Journal of Dermatology·Sarah ShenChristopher J McCormack
Feb 1, 1989·The West Virginia Medical Journal·J E BrickA G DiBartolomeo
Nov 15, 1997·Rheumatic Diseases Clinics of North America·C A LangfordG S Hoffman
Nov 15, 1997·Rheumatic Diseases Clinics of North America·W S Wilke
Apr 6, 2002·Journal of Wound Care·E R McRorie
Apr 1, 1988·Journal of Clinical Pharmacy and Therapeutics·D G Scott
Jul 10, 2020·La Presse médicale·Robert G Micheletti, Christian Pagnoux
Mar 15, 2003·Journal of the American Academy of Dermatology·David F Fiorentino
Feb 1, 1995·Seminars in Arthritis and Rheumatism·J M AnayaL R Espinoza
Jul 2, 2021·Current Rheumatology Reports·Joana Martins-MartinhoCristina Ponte

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