Oral microbiota and oral cancer: Review

Oncology Reviews
Mariam Z KakabadzeZurab Kakabadze

Abstract

In this review, we draw attention and discuss the risk factors and causes of the development of oral squamous cell carcinoma (OSCC) focusing on oral microbiota. Recently, a breakthrough in the study of cancer has been the discovery of the relationship between the presence of certain types of bacteria and the development of cancer in the human body. Studies have shown that, Porphyromonas gingivalis (P. gingivalis) bacteria that is responsible for the destructive processes in the oral cavity, could play an important role in the development of OSCC. In our continuing search for bacteria that causes oral squamous cell carcinoma, we came across the Pseudomona aeruginosa, which due to its metabolite properties, may play important role in carcinogenesis of oral cancer. One possible mechanism is the ability of Pseudomonas to synthesize nitric oxide (NO) that modulates different cancer-related appearances such as apoptosis, cell cycle, angiogenesis, invasion, and metastasis. We think that P. aeruginosa increases the concentration of NO by converting salivary nitrite to nitric oxide, and this is how it contributes to NO-related carcinogenesis. Early diagnosis and treatment of periodontitis are very important not only for patients' oral h...Continue Reading

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Citations

Nov 17, 2020·Frontiers in Immunology·Muhammad IrfanJorge Frias-Lopez
Mar 23, 2021·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Tomás G VillaCarmen Sieiro
Jun 7, 2021·Journal of Microbiological Methods·Naurú Idalia Vargas-MayaBernardo Franco
Jul 18, 2021·BMC Oral Health·Simone G OliveiraFlavio H B Aguiar
Aug 28, 2021·Microorganisms·Tereza VyhnalovaPetra Borilova Linhartova
Oct 17, 2021·Applied Microbiology and Biotechnology·Peng YeZhi-Yue Lu

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BETA
biopsies

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