Oral Microbiota Community Dynamics Associated With Oral Squamous Cell Carcinoma Staging

Frontiers in Microbiology
Chia-Yu YangYu-Liang Chang

Abstract

Oral squamous cell carcinoma (OSCC) is a highly aggressive cancer and the fourth leading malignancy among males in Taiwan. Some pathogenic bacteria are associated with periodontitis and oral cancer. However, the comprehensive profile of the oral microbiome during the cancer's progression from the early stage to the late stage is still unclear. We profiled the oral microbiota and identified bacteria biomarkers associated with OSCC. The microbiota of an oral rinse from 51 healthy individuals and 197 OSCC patients at different stages were investigated using 16S rRNA V3V4 amplicon sequencing, followed by bioinformatics and statistical analyses. The oral microbiota communities from stage 4 patients showed significantly higher complexity than those from healthy controls. The populations also dynamically changed with the cancer's progression from stage 1 to stage 4. The predominant phyla in the oral samples showed variation in the relative abundance of Fusobacteria, Bacteroidetes, and Actinobacteria. The abundance of Fusobacteria increased significantly with the progression of oral cancer from the healthy controls (2.98%) to OSCC stage 1 (4.35%) through stage 4 (7.92%). At the genus level, the abundance of Fusobacterium increased, whi...Continue Reading

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Citations

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Methods Mentioned

BETA
electrophoresis
biopsy
PCR
PCA

Software Mentioned

R scripts
Cutadapt
SPSS
USEARCH
Phylogenetic Investigation of Communities by Reconstruction of...
MiSeq Reporter
metagenomeSeq
FLASH
LEfSe
BLASTN

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