PMID: 9549736Apr 29, 1998Paper

Oral midazolam premedication and postoperative behaviour in children

Paediatric Anaesthesia
T McGraw, A Kendrick

Abstract

We examined the effect of oral midazolam premedication on postoperative behaviour. Seventy children (ASA Physical Status 1 and 2; aged 1-10 yrs) were assigned randomly in a prospective, blinded fashion to receive either midazolam 0.5 mg.kg-1 (maximum 10 mg) or placebo. Behaviour assessments were made prior to medication, during induction of anaesthesia and 15 min following arrival to recovery room. The baseline behavioural evaluation scores were not significantly different. The children receiving midazolam cried significantly less during induction (P < or = 0.02). At one week follow-up, eight of 35 subjects receiving placebo had experienced adverse behaviour changes (nightmares, night terrors, food rejection, anxiety, negativism); 19 of 35 of the midazolam group experienced these changes (P < or = 0.02). At four week follow-up, most behaviour changes had resolved. Children given preoperative oral midazolam were less likely to cry and fight while being anaesthetized, and preoperative sedation was associated with increased incidence of adverse postoperative behaviour changes.

Associated Clinical Trials

Sep 26, 2014·Madhankumar Sathyamoorthy, Madhankumar Sathyamoorthy

References

Apr 1, 1991·Anesthesia and Analgesia·F X DillonM Glass
Nov 1, 1990·Anesthesiology·L H FeldP F White
Jan 1, 1989·European Journal of Clinical Pharmacology·K PayneT Dawes
Mar 1, 1970·Canadian Anaesthetists' Society Journal·P M McGarry
Feb 1, 1967·Journal of Personality and Social Psychology·D T VernonJ L Schulman
Jun 1, 1966·American Journal of Diseases of Children·D T VernonJ M Foley
Nov 1, 1981·Clinical Pharmacology and Therapeutics·H AllonenU Klotz
Jan 1, 1983·British Journal of Clinical Pharmacology·C CrevoisierP Heizmann
May 1, 1983·Canadian Anaesthetists' Society Journal·R S Hannallah, J K Rosales
May 1, 1984·Anesthesiology·R M BrzustowiczD B Swedlow

❮ Previous
Next ❯

Citations

Aug 18, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H ViitanenA Yli-Hankala
Dec 5, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Robin G CoxMarie-Josée Crowe
Apr 3, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·D Cohen-Salmon
Feb 5, 2014·Anesthesiology Clinics·Richard J Banchs, Jerrold Lerman
Jan 19, 2016·Journal of Paediatrics and Child Health·Neda Taghizadeh, Andrew Davidson
Aug 4, 2009·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Constance N BurkeShobha Malviya
May 27, 2009·International Journal of Pharmaceutics·Frédéric MarçonFlorence Djedaini-Pilard
Sep 29, 2007·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Terri Voepel-LewisShobha Malviya
Mar 25, 2005·Paediatric Anaesthesia·Per-Arne Lönnqvist, Walid Habre
Mar 25, 2005·Paediatric Anaesthesia·Séverine CalipelClaude Ecoffey
Aug 22, 2006·Paediatric Anaesthesia·Andrew J DavidsonRobyn Stargatt
Sep 16, 2006·Paediatric Anaesthesia·Anuradha PatelHenry Bennett
Nov 8, 2007·Paediatric Anaesthesia·Nicole AlmenraderPaolo Pietropaoli
Apr 28, 2007·Acta Paediatrica·M KarlingB Hägglöf
Mar 16, 2007·Paediatric Anaesthesia·Christian BreschanRudolf Likar
Oct 14, 2016·Journal of Paediatrics and Child Health·Yongfu ZhangJianxin Lao
Dec 21, 2006·Behavior Modification·Kristi D WrightSusan E Buffett-Jerrott
Jan 29, 2014·The Cochrane Database of Systematic Reviews·Paul LambertPhilippa Middleton
Mar 15, 2006·Current Opinion in Anaesthesiology·Philip D Bailey, John L Bastien
Mar 15, 2006·Current Opinion in Anaesthesiology·Henrik BergendahlStaffan Eksborg
Sep 27, 2012·Anesthesia and Analgesia·Jeongwoo LeeSeonghoon Ko
Oct 5, 2006·Current Opinion in Anaesthesiology·Z N Kain
Mar 19, 2003·Paediatric Anaesthesia·Agnes T Watson, Anil Visram
Apr 1, 2012·Anesthesiology and Pain Medicine·Ravi K VermaSurendra Gupta
Jun 29, 2001·Anesthesia and Analgesia·M E McCann, Z N Kain
Jan 8, 2011·Paediatric Anaesthesia·Marzena ZielinskaAndrew Wolf
Dec 14, 2018·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Kirstie L WalkerMateen Raazi
Nov 8, 2003·The Journal of Clinical Pediatric Dentistry·Yuri Goldvasser, Kell Julliard
Jan 29, 2017·Paediatric Drugs·Christopher HuettRichard K Ellerkmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
D M Laskin
© 2022 Meta ULC. All rights reserved