Oral misoprostol versus oxytocin in the management of the third stage of labour

Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC
Steven M ParsonsDonna Hutchens

Abstract

To compare the effects of oral misoprostol 800 mug with intramuscular oxytocin 10 IU in routine management of the third stage of labour. This randomized controlled trial was performed in a rural district hospital in Ghana, West Africa, and enrolled women in labour with anticipated vaginal delivery and no known medical contraindication to prostaglandin administration. Women were randomized to receive oral misoprostol 800 mug or intramuscular oxytocin 10 IU. Blood samples were taken to determine hemoglobin concentration before delivery and at 12 hours post partum. Treatment was administered at delivery of the anterior shoulder. The primary outcome was the change in hemoglobin concentration from before to after delivery. Secondary outcomes included other measures of blood loss and presumed medication side effects. In total, 450 women were enrolled in the study. Their baseline characteristics were similar. There was no significant difference between the groups in the change in hemoglobin concentration (misoprostol 1.07 g/dL and oxytocin 1.00 g/dL). The only significant secondary outcomes were shivering (80.7% with misoprostol vs. 3.6% with oxytocin) and pyrexia (11.4% with misoprostol, none with oxytocin). Routine use of oral misop...Continue Reading

Citations

Feb 27, 2007·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·T F BaskettD C Young
Apr 28, 2010·Archives of Gynecology and Obstetrics·H A Mansouri, N Alsahly
Jan 12, 2012·Expert Opinion on Investigational Drugs·Wendy R SheldonBeverly Winikoff
Jul 17, 2013·The Cochrane Database of Systematic Reviews·G Justus HofmeyrTheresa A Lawrie
Aug 17, 2012·The Cochrane Database of Systematic Reviews·Özge TunçalpA Metin Gülmezoglu
Apr 4, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Abdulkarim O MusaIshaq F Abdul
Apr 26, 2018·The Cochrane Database of Systematic Reviews·Ioannis D GallosArri Coomarasamy
Dec 21, 2018·The Cochrane Database of Systematic Reviews·Ioannis D GallosArri Coomarasamy
Mar 2, 2019·Health Technology Assessment : HTA·Ioannis GallosArri Coomarasamy

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