Oral ofloxacin therapy of Pseudomonas aeruginosa sepsis in mice after irradiation.

Antimicrobial Agents and Chemotherapy
I Brook, G D Ledney

Abstract

Death subsequent to whole-body irradiation is associated with gram-negative bacterial sepsis. The effect of oral therapy with the new quinolone ofloxacin for orally acquired Pseudomonas aeruginosa infection was tested in B6D2F1 mice exposed to 7.0 Gy of bilateral radiation from 60Co. A dose of 10(7) organisms was given orally 2 days after irradiation, and therapy was started 1 day later. Only 4 of 20 untreated mice (20%) survived for at least 30 days compared with 19 of 20 mice (95%) treated with ofloxacin (P less than 0.005). P. aeruginosa was isolated from the livers of 21 to 28 untreated mice (75%), compared with only 2 of 30 treated mice (P less than 0.005). Ofloxacin reduced colonization of the ileum by P. aeruginosa; 24 of 28 untreated mice (86%) harbored the organisms, compared with only 5 of 30 (17%) with ofloxacin (P less than 0.005). This experiment was replicated twice, and similar results were obtained. These data illustrate the efficacy of the quinolone ofloxacin for oral therapy of orally acquired P. aeruginosa infection in irradiated hosts.

References

Aug 7, 1987·JAMA : the Journal of the American Medical Association·R P Gale
May 1, 1988·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·I BrookT J MacVittie
Jan 1, 1987·Antimicrobial Agents and Chemotherapy·S PecquetC Tancrède
Sep 1, 1986·Canadian Journal of Microbiology·I BrookT J MacVittie
Oct 1, 1984·Infection and Immunity·I BrookR I Walker
Mar 1, 1981·The American Journal of Medicine·D G Maki

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Citations

Oct 17, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Vesta ValuckaiteJohn C Alverdy
Jan 1, 1992·Critical Reviews in Microbiology·I Brook, G D Ledney
Jun 2, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Daniel WeisdorfDennis Confer

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