PMID: 6981170Mar 1, 1982Paper

Oral or intravenous trimethoprim-sulfamethoxazole therapy for shigellosis

Reviews of Infectious Diseases
J D NelsonS Shelton

Abstract

A review of the literature concerning shigellosis treated with trimethoprim-sulfamethoxazole (TMP-SMZ) revealed comparative studies of 149 cases and noncomparative studies of 147 cases. Bacteriologic and clinical success rates were greater than or equal to 90% and TMP-SMZ compared favorably with alternative drug therapy. In the present study TMP-SMZ was given intravenously as initial therapy to 11 children hospitalized for severe shigella colitis. Bacteriologic and clinical responses were comparable to those observed with oral TMP-SMZ therapy. Pharmacokinetic studies revealed substantial differences between the responses of these children and those reported for adult patients; a higher ratio of SMZ to TMP (50:1) was found in children. It is concluded that TMP-SMZ is effective therapy for shigellosis and is the drug of choice in areas where ampicillin resistance is prevalent.

Citations

Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·M J Farthing
Jun 1, 1993·Baillière's Clinical Gastroenterology·D A Scott, R Edelman
Dec 1, 1991·Mayo Clinic Proceedings·F R Cockerill, R S Edson
Jul 1, 1985·Antimicrobial Agents and Chemotherapy·J C EngleC J Schleupner
Jul 1, 1986·Antimicrobial Agents and Chemotherapy·T A TartaglioneG D Qureshi
Nov 18, 2014·Expert Review of Anti-infective Therapy·Karl C Klontz, Nalini Singh

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