Oral pentamidine-loaded poly(d,l-lactic-co-glycolic) acid nanoparticles: an alternative approach for leishmaniasis treatment

Nanotechnology
Isabela Viol VallePlínio Cunha Sathler

Abstract

Leishmaniasis is a group of diseases caused by a protozoa parasite from one of over 20 Leishmania species. Depending on the tissues infected, these diseases are classified as cutaneous, mucocutaneous and visceral leishmaniasis. For the treatment of leishmaniasis refractory to antimony-based drugs, pentamidine (PTM) is a molecule of great interest. However, PTM displays poor bioavailability through oral routes due to its two strongly basic amidine moieties, which restricts its administration by a parenteral route and limits its clinical use. Among various approaches, nanotechnology-based drug delivery systems (nano-DDS) have potential to overcome the challenges associated with PTM oral administration. Here, we present the development of PTM-loaded PLGA nanoparticles (NPs) with a focus on the characterization of their physicochemical properties and potential application as an oral treatment of leishmaniasis. NPs were prepared by a double emulsion methodology. The physicochemical properties were characterized through the mean particle size, polydispersity index (PdI), zeta potential, entrapment efficiency, yield process, drug loading, morphology, in vitro drug release and in vivo pharmacological activity. The PTM-loaded PLGA NPs p...Continue Reading

References

Jul 1, 1996·The Journal of Antimicrobial Chemotherapy·G BanerjeeM K Basu
Jan 9, 1998·International Journal for Parasitology·R DurandM Deniau
Jan 1, 1995·Critical Reviews in Therapeutic Drug Carrier Systems·E Albers, B W Müller
May 20, 1998·Parasite : Journal De La Société Française De Parasitologie·R DurandM Deniau
Jan 17, 2004·International Journal of Pharmaceutics·Richard A GravesTarun K Mandal
Aug 5, 2006·Biochimica Et Biophysica Acta·Andreas FritzeRegine Peschka-Süss
Aug 15, 2006·PLoS Medicine·Luis Fernando Chaves, Mercedes Pascual
Nov 15, 2006·International Journal of Pharmaceutics·Weiling HeM Delwar Hussain
Dec 29, 2006·Chemistry & Biodiversity·Paul A NguewaJosé M Pérez
Mar 10, 2007·Journal of Magnetic Resonance Imaging : JMRI·Samuel A WicklineGregory M Lanza
Mar 14, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·G MittalM N V Ravi Kumar
Sep 11, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Marie GaumetFlorence Delie
Sep 18, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Richard C MurdockSaber M Hussain
Aug 21, 2008·Pharmaceutical Research·Paolo DecuzziMauro Ferrari
Mar 12, 2009·Current Drug Targets·Angela Kaysel CruzChairat Uthaipibull
Jul 21, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Ratul Kumar DasUtpal Bora
Aug 25, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fabienne DanhierVéronique Préat
Jul 8, 2010·Journal of Global Infectious Diseases·E M Moore, D N Lockwood
Sep 22, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S L Croft, P Olliaro
Oct 11, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·R LopesA J Almeida
Oct 11, 2011·ChemMedChem·Joscha KotthausBernd Clement
Nov 25, 2011·International Journal of Nanomedicine·Simona MuraElias Fattal
May 12, 2012·Polymers·Hirenkumar K Makadia, Steven J Siegel
Jun 14, 2012·PloS One·Jorge AlvarUNKNOWN WHO Leishmaniasis Control Team
Jul 13, 2012·International Journal of Nanomedicine·Luiz Cláudio da SilvaLúcio M Cabral
Apr 26, 2013·Critical Reviews in Therapeutic Drug Carrier Systems·Daniel J Hines, David L Kaplan
May 17, 2013·Recent Patents on Anti-cancer Drug Discovery·Jose PradosAntonia Aranega
Jul 23, 2013·International Journal of Pharmaceutics·T T H PhamG Barratt
Aug 13, 2013·Advanced Drug Delivery Reviews·Fernanda AndradeBruno Sarmento
Feb 20, 2014·International Journal of Pharmaceutics·Hema ChaudharyVikash Kumar
Aug 5, 2014·Journal of Colloid and Interface Science·Muzamil Yaqub WantFarhat Afrin
Dec 3, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·José L AriasJosé A García-Salcedo
Feb 24, 2015·AAPS PharmSciTech·Deepak SharmaShweta Dang
May 7, 2015·Journal of Nanoscience and Nanotechnology·Muhammad QasimDokyun Na
Jun 17, 2015·BioMed Research International·Juliana Perrone Bezerra de MenezesPatrícia Sampaio Tavares Veras
Oct 20, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Narjara SilveiraPriscilla V Finotelli
Jan 7, 2016·Anais Brasileiros De Dermatologia·Ellen Priscilla Nunes GadelhaAnette Chrusciak Talhari
Jan 17, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hinojal ZazoJosé M Lanao

❮ Previous
Next ❯

Citations

Apr 17, 2021·Journal of Nanobiotechnology·Humzah JamshaidGul Majid Khan
Apr 30, 2021·International Journal of Pharmaceutics·Renata Ribeiro de CastroBruno Sarmento
Jun 4, 2021·International Journal of Pharmaceutics·Olga Kammona, Evgenia Tsanaktsidou

❮ Previous
Next ❯

Related Concepts