PMID: 8959457Nov 1, 1996Paper

Oral pharmacotherapy for the movement disorders of cerebral palsy

Journal of Child Neurology
M R Pranzatelli

Abstract

Movement disorders are a well-recognized feature of some patients with cerebral palsy and often require treatment. However, treatments have been symptomatic and empiric, and there have been few pharmacologic studies. The major movement disorders in cerebral palsy are dystonia and the hyperkinesias choreoathetosis and myoclonus. They may occur in combination, often accompanied by spasticity and sometimes by epilepsy. Some drugs are useful treatments for all of these problems, but others may improve one while worsening another. Pitfalls in management include not diagnosing metabolic/degenerative disorders, which may mimic cerebral palsy, or not recognizing reversible complications of cerebral palsy, which may exacerbate symptoms. This review attempts to summarize empiric drug use and recommendations for therapy, drug studies in extrapyramidal cerebral palsy, and prospects for new drugs or models for the problem. Many new pharmacologic agents are available for study in cerebral palsy. Better methods of detecting basal ganglia injury after perinatal injury in asymptomatic infants may allow early intervention in the biologic process of recovery and adaptation.

References

Aug 1, 1992·Clinical Neuropharmacology·P Greene
Jan 1, 1992·Acta Paediatrica·J Foley
Jul 1, 1990·Trends in Neurosciences·M R DeLong
Aug 1, 1991·Acta paediatrica Scandinavica·K YokochiS Fujimoto
Oct 1, 1989·Trends in Neurosciences·R L AlbinJ B Penney
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J A KempG N Woodruff
Feb 1, 1985·Annals of Neurology·R A Davidoff
Dec 1, 1988·Clinical Neuropharmacology·J A ObesoC D Marsden
Mar 1, 1988·The Annals of Otology, Rhinology, and Laryngology·Y P TalmiN Laurian
Jan 1, 1972·Neurology·R K RosenthalW Cooper
Oct 1, 1971·Neuropädiatrie·I Bjerre, G Blennow
Jan 1, 1964·Annals of Physical Medicine·G C Kanjilal
Jul 1, 1967·Journal of the Neurological Sciences·J B Cook, P W Nathan
Apr 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·J Foley
Jul 1, 1982·Italian Journal of Neurological Sciences·M PapiniA Pasquinelli
Feb 1, 1981·Annals of Neurology·J E RiceJ B Brierley
Jan 1, 1994·Annual Review of Neuroscience·R L Macdonald, R W Olsen
Nov 1, 1993·Pediatric Neurology·E J CandyR N Bryan
Oct 1, 1994·Journal of Child Neurology·A K Afifi
Oct 1, 1994·Pediatric Neurology·T G NygaardA M Chutorian
Mar 3, 1994·The New England Journal of Medicine·S A Lipton, P A Rosenberg
Jul 1, 1994·Journal of Child Neurology·A K Afifi
May 1, 1994·Brain Research. Brain Research Reviews·A H Gouliaev, A Senning
Jan 1, 1993·Pediatric Annals·H L Klawans, M M Brandabur
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·N G Bowery
Jul 1, 1993·Journal of the Neurological Sciences·M DahlinA Nergårdh
Jun 1, 1993·American Journal of Physical Medicine & Rehabilitation·S A Yablon, M L Sipski
Jun 1, 1995·Clinical Neuropharmacology·J Jankovic
Aug 1, 1995·Clinical Neuropharmacology·M Malcangio, N G Bowery
Sep 1, 1996·Journal of Child Neurology·M R Pranzatelli
Mar 8, 1965·JAMA : the Journal of the American Medical Association·H O MARSH

❮ Previous
Next ❯

Citations

Dec 14, 1999·Anaesthesia·J NolanT C Brown
May 23, 2012·PM & R : the Journal of Injury, Function, and Rehabilitation·Dwan PerrySusan McDowell
Jul 31, 2008·Nature Clinical Practice. Neurology·Barry S Russman
Feb 18, 2006·Developmental Medicine and Child Neurology·Robin Nemer McCoyJean P O'Malley
Nov 30, 2000·Current Treatment Options in Neurology·B S Russman
Aug 11, 2007·Journal of Child Neurology·Terence D SangerUNKNOWN Child Motor Study Group
Feb 28, 2001·Journal of Child Neurology·J E Brunstrom

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

The Medical Journal of Australia
J E Rice, P D Thompson
Parkinsonism & Related Disorders
Raja Mehanna, Joseph Jankovic
Parkinsonism & Related Disorders
David MaltêteDidier Hannequin
Parkinsonism & Related Disorders
Pierre R Burkhard
© 2021 Meta ULC. All rights reserved