Oral, post-oral and genetic interactions in sweet appetite.

Physiology & Behavior
Anthony Sclafani

Abstract

Inbred mouse strains differ in their preferences for sweeteners, due in part to variations in their T1R3 sweet taste receptor. Recent studies of sweet sensitive C57BL/6J (B6) and subsensitive 129P3/J (129) mice indicate that experiential and post-oral effects of sugar substantially modify sweetener preference. In fact, the strain difference in sucrose preference disappeared after the mice were given 23 h/day tests with sucrose at ascending concentrations (0.5-32%). Intragastric infusions of sucrose (16%) also conditioned increased preference for and absolute intake of flavored sweet solutions in B6 and 129 mice. An operant analysis of sweetener appetite revealed, unexpectedly, that sugar-experienced 129 mice respond more vigorously than B6 mice for 16% sucrose rewards. These findings indicate that experiential and nutritional factors can, to some degree, override genetic differences in peripheral taste sensitivity in determining food appetite.

References

Feb 1, 1976·Physiology & Behavior·I Ramirez, J L Fuller
Jan 1, 1974·Journal of Comparative and Physiological Psychology·M D Stockton, G Whitney
Oct 1, 1994·Chemical Senses·J A Rhinehart-DotyG P Smith
Jul 14, 1998·Physiology & Behavior·B S Kotlus, D A Blizard
Jun 17, 1999·Pharmacology, Biochemistry, and Behavior·S Reilly
Feb 15, 2001·Mammalian Genome : Official Journal of the International Mammalian Genome Society·X LiA A Bachmanov
Aug 18, 2001·Cell·G NelsonC S Zuker
Sep 14, 2001·Chemical Senses·A A BachmanovG K Beauchamp
Sep 14, 2001·Chemical Senses·A A BachmanovG K Beauchamp
Jul 26, 2002·Current Opinion in Neurobiology·Jean Pierre Montmayeur, Hiroaki Matsunami
Jul 19, 2003·Science·Sami DamakRobert F Margolskee
Sep 5, 2003·Physiology & Behavior·Anthony Sclafani, Karen Ackroff
Sep 5, 2003·Physiology & Behavior·Anthony Sclafani, John I Glendinning
Nov 26, 2003·Cell·Grace Q ZhaoCharles S Zuker
Jan 30, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·D R ReedA A Bachmanov
Mar 6, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masashi InoueAlexander A Bachmanov
Jul 6, 2004·Physiology & Behavior·Anthony Sclafani
Aug 25, 2004·Behavioural Brain Research·Stéphanie PothionCatherine Belzung
Jan 26, 2005·Biochemical Society Transactions·J DyerS P Shirazi-Beechey
Apr 23, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anthony Sclafani, John I Glendinning
Jul 6, 2005·Physiology & Behavior·Sarah R LewisRichard J Bodnar
Sep 2, 2005·Chemical Senses·John I GlendinningKun Hao Zheng
Feb 14, 2008·Pure and Applied Chemistry. Chimie Pure Et Appliquée·Alexander A BachmanovGary K Beauchamp

❮ Previous
Next ❯

Citations

Nov 26, 2010·The Proceedings of the Nutrition Society·E FeeneyE R Gibney
Apr 24, 2010·Chemical Senses·Anthony SclafaniKaren Ackroff
May 9, 2012·Chemical Senses·Marion E FrankThomas P Hettinger
Apr 24, 2008·Annual Review of Nutrition·Stephen C WoodsDaniela Cota
Dec 19, 2008·PloS One·Cedrick D DotsonSteven D Munger
Feb 18, 2011·Physiology & Behavior·Maik Behrens, Wolfgang Meyerhof
Dec 22, 2007·NeuroImage·Guido K W FrankWalter H Kaye
Sep 4, 2007·Physiology & Behavior·Alexander A Bachmanov, Gary K Beauchamp
Jun 21, 2012·The European Journal of Neuroscience·Jeff A BeelerXiaoxi Zhuang
May 11, 2015·Physiology & Behavior·James Edgar McCutcheon
Mar 27, 2012·Physiology & Behavior·Anthony Sclafani, Karen Ackroff
Mar 26, 2015·Nature Communications·Emily E LeDueMichael D Gordon
Jun 21, 2016·Nature Neuroscience·Gwenaël LabouèbeBernard Thorens
Sep 2, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K Ganesh KumarBrenda K Smith Richards
Apr 8, 2014·American Journal of Medical Genetics. Part a·Setareh AshtianiJehannine Austin
Jul 12, 2011·Flavour and Fragrance Journal·Alexander A BachmanovGary K Beauchamp
May 21, 2020·Diabetes & Metabolism Journal·Kerstin RohdeMatthias Blüher
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Andrew J TaylorCharles Spence
Mar 14, 2021·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Cailu LinDanielle R Reed
Jun 23, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lihong HaoNicholas T Bello

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.